| ABSTRACT Objective:To analyze the characteristics of adverse drug reactions(ADR), in order to provide a reference for ADR monitoring and medication safety. Methods:1 463 cases of new/serious ADR reporting were collected from the national ADR monitoring system of Xiaogan City from 2011 to 2015. The data of patients’ sex, age, drug categories, and route of administration, ADR involving organ / system and clinical manifestations were analyzed. Results:Most ADR caused by anti infectives and traditional Chinese medicine injections in the report of 1 463 cases. 837 cases (57.24%) caused by the intravenous infusion administration. 1 088 cases (74.37%) ADR occurred within 2h of administration. Damage caused by the new general ADR was skin and its appendages, and the gastrointestinal system and systemic. Serious ADR cause the damage of systemic, and skin and its appendages and central and peripheral nervous system. High frequency drugs of the new / serious ADR were Xiangdan injection， Shenmai injection，levofloxacin，ceftriaxone，cefuroxime etc. Conclusion:The main drug leaded to new / severe ADR happens was anti infective drugs and traditional Chinese medicine injections, and the common serious ADR was allergies, and the drug caused serious consequences of ADR was High Alert Medicines, therefore, ADR monitoring must focus on these drugs, so as to minimize the risk of ADR. |
