| ABSTRACT Objective:To evaluate risk and benefit of antidepressant using analytic hierarchy process (AHP), comprehensive scores of each antidepressant were obtained and ranked for clinical rational use of drug.Methods:The AHP disaggregates a complex decision problem into different hierarchical levels. The first step involve defining the goal of the decision. In the next step, identifying criteria, the risk and benefit of antidepressants can be assessed independently. And finally, making comparisons among the alternatives. The hierarchical decision model was defined, then relevant literature of Meta analysis were searched to confirm the relative importance of each attributive. The risk value, benefit value and comprehensive score were obtained by using the AHP. The Expert Choice software was used for the sensitivity analysis. Results:The comprehensive scores of mirtazapine, venlafaxine, citalopram and sertraline were 0.305 4, 0.304 6, 0.294 6 and 0.095 4, respectively. The benefit value of mirtazapine, venlafaxine, citalopram and sertraline were 0.313 0, 0.313 0, 0.313 0 and 0.063 0, respectively. The risk value of mirtazapine, venlafaxine, citalopram and sertraline were 0.196 2, 0.282 0, 0.353 5 and 0.168 9, respectively. The consistency ratio (CR) of judgment matrix were less than 0.1, which passed the consistency inspection. Conclusion:The highest comprehensive scores was mirtazapine and the lowest one was sertraline. sertraline had the lowest benefit value and citalopram had the highest risk value. |
