| ABSTRACT Objective:To investigate the clinical characteristics and announcements of adverse drug reactions (ADRs) induced by thiamazole.Methods:Base on a case of interstitial pneumonia induced by thiamazole in our hospital, literature about ADRs due to thiamazole were searched from CNKI, Wanfang, VIP, PubMed database. The gender and age of patients with ADRs, clinical manifestations, system organ damages will be analyzed. Results:67 literatures were collected; a total of 91 cases were included in the analysis. The proportion of ADRs occurring was higher in women than men, the ratio was about 3∶1. The most dosage was 30 mg·d-1. ADRs occurred between 1 day to 3 years after medications, most within 1 month. ADRs involved 7 system organs, including the blood system, bone and joint, digestive system, respiratory and endocrine system and so on. The most serious adverse reaction was death caused by severe agranulocytosis. Naranjo's ADR probability scale was used to evaluate relevance. Except 7 cases of suspected, the other ADRs were associated with thiamazole. Conclusion:There are more attention should pay to the ADRs due to thiamazole. The blood and liver function should be monitored during medication, to make sure the safety of patients. |
