| ABSTRACTOxaliplatin induced neuropathy, which had unique clinical features, was one of the most common adverse effects associated with oxaliplatin administration. The exact mechanism of oxaliplatin induced neurotoxicity was not known and no effective prevention and treatment methods had been developed. Several recent studies had found that transient receptor potential channels, gap junction channels, nicotinic acetylcholine receptors and so on may mediate the neurotoxicity of oxaliplatin, with which genetic polymorphisms were also significantly associated. Mangafodipir, ganglioside monosialic acid, and Astragali radix extracts and so on had shown preventive and therapeutic effects in clinical studies. In this article, new progress in the pathogenesis and treatment of oxaliplatin induced neurotoxicity were reviewed. |
