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醋酸曲普瑞林与醋酸亮丙瑞林缓释微球治疗特发性中枢性早熟临床效果比较

Clinical Efficacy Comparison of Triptorelin Acetate and Leuprolide Acetate Microspheres in the Treatment of Idiopathic Central Precocious Puberty

DOI：

中文关键词: 醋酸曲普瑞林醋酸亮丙瑞林缓释微球特发性中枢性早熟疗效

英文关键词:Triptorelin acetate Leuprolide acetate microspheres Iidiopathic central precocious puberty Curative effect

基金项目:

作者	单位
章铭^① 沈文霞^②	绍兴市妇幼保健院 ①药剂科；②内科（浙江绍兴312000）

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中文摘要:

摘要目的：比较醋酸曲普瑞林与醋酸亮丙瑞林缓释微球治疗特发性中枢性早熟的临床效果。方法：将特发性中枢性早熟女童74例随机分为A组与B组各37例。A组予醋酸曲普瑞林治疗，B组予醋酸亮丙瑞林缓释微球治疗。两组疗程均为6个月。比较两组治疗前后性激素水平、BA/CA、身高、体重指数、子宫体积、卵巢体积变化及药品不良反应发生情况。结果：两组治疗后血清FSH、E2、LH水平较前明显下降（P<0.05）；且A组血清FSH、E2、LH水平显著低于B组（P<0.05），治疗前后血清FSH、E2、LH差值明显高于B组（P<0.05）。两组BA/CA和体重指数较前明显下降，身高较前明显增加（P<0.05）；且A组BA/CA和体重指数显著低于B组，身高显著高于B组（P<0.05）；A组治疗前后BA/CA、身高及体重指数差值均高于B组（P<0.05）。治疗后两组子宫体积和卵巢体积均较前明显降低（P<0.05），且A组子宫体积和卵巢体积显著低于B组（P<0.05），治疗前后子宫体积和卵巢体积差值高于B组（P<0.05）。两组药品不良反应发生率的差异无统计学意义（P>0.05）。结论：醋酸曲普瑞林用于特发性中枢性早熟患儿效果优于醋酸亮丙瑞林缓释微球，且无严重不良反应，用药安全性良好。

英文摘要:

ABSTRACT Objective:To compare the clinical effect of triptorelin acetate and leuprolide acetate microspheres in the treatment of idiopathic central precocious puberty. Methods:74 children with idiopathic central precocious puberty were selected and divided into group A and group B at random, each 37 cases. Group A was given triptorelin acetate treatment, group B was given leuprolide acetate microspheres. The course of treatment of two groups were 6 months. Compared the two groups before and after the treatment of sex hormone levels, BA/CA, height, body mass index, uterine volume, ovarian volume change, and adverse reactions occurred. Results:The serum FSH, E2 and LH levels after treatment in the two groups decreased significantly (P<0.05); serum FSH, E2 and LH levels after treatment in group A were lower than which in the group B (P<0.05); Before and after treatment, the differences of serum FSH, E2 and LH in group A were significantly higher than those in group B (P<0.05); BA/CA and body mass index of two groups decreased after treatment, while the height increased significantly (P<0.05); The BA/CA and body mass index after treatment in group A were lower than that of B group, while the height after treatment was higher than that of group B (P<0.05); the volume of uterus and ovarian decreased after treatment (P<0.05); the volume of uterus and ovarian of group A was lower than that of group B after the treatment (P<0.05); the difference of volume of uterus and ovary in group A was higher than that in group B (P<0.05), and there was no significant difference in incidence of adverse reactions between the two groups (P>0.05). Conclusion:The curative effect of triptorelin acetate for idiopathic central precocious puberty was better than that of leuprolide acetate microspheres, and it had no serious adverse reactions, the medication safety was good.

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