| ABSTRACT Objective:To analyze the pathogens distribution and drug resistance in patients on severe community acquired pneumonia in respiratory medicine, so as to provide appropriate clinical treatment. Methods: By retrospective analysis of 283 cases of pathogens distribution and drug resistance in bronchoalveolar lavage fluid with 283 severe community acquired pneumonia patients. Results: A total of 163 strains of pathogenic bacteria were isolated, Gram negative(G-) bacteria strain 114, accounted for 69.94%, Gram positive bacteria(G+) strain 43, accounted for 26.38%, and fungus strain 6, accounted for 3.68%. The top four G- were klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii; the top three G+ were Streptococcus pneumoniae, Staphylococcus aureus, enterococcus faecalis. The results of drug sensitivity test showed that klebsiella pneumoniae, Escherichia coli were sensitive to cefazolin, imipenem, cefotetan and piperacillin tazobactam, amikacin; Pseudomonas aeruginosa, Acinetobacter baumannii were drug resistant severe, high resistance to a variety of antimicrobial agents. Streptococcus pneumoniae, Staphylococcus aureus were sensitive to piperacillin tazobactam, cefradine, rifampicin, levofloxacin, etc. Enterococcus faecaliswere multiple drug resistant bacteria, not detected with vancomycin resistant G+ strains. Fungus were relatively rare, to amphotericin B, voriconazole, etc were more sensitive. Conclusion: In all the pathogens of severe community acquired pneumonia, G-was the majority . It should choose reasonable anti infection treatment in clinical according to the results of drug susceptibility, so as to delay the spread of drug resistant strains, reduce the emergence of new drug resistant strains. |
