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| 加味酸枣仁汤联合帕罗西汀治疗广泛性焦虑障碍并阴虚火旺型患者临床观察 |
| Efficacy Observation of Modified Suanzaoren Decoction Combined with Paroxetine in the Treatment of Generalized Anxiety Disorder with Yin deficiency and Fire excess Syndrome |
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| DOI： |
| 中文关键词: 广泛性焦虑障碍 阴虚火旺型 帕罗西汀 加味酸枣仁汤 |
| 英文关键词:Generalized anxiety disorder Yin deficiency and fire excess syndrome Paroxetine Modified suanzaoren decoction |
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| 中文摘要: |
| 摘 要 目的：探讨加味酸枣仁汤联合帕罗西汀治疗广泛性焦虑障碍并阴虚火旺型患者的疗效和安全性。方法：104例广泛性焦虑患者随机分为对照组（帕罗西汀治疗）和观察组（加味酸枣仁汤联合帕罗西汀治疗）各52例，两组疗程均为4周。治疗前和治疗每周末用汉密尔顿焦虑量表（HAMA）和焦虑自评量表（SAS）评估临床疗效，以副反应量表（TESS）评估药品不良反应。结果：治疗1～3周末，观察组HAMA总分、SAS评分以及有效率均明显优于对照组(P< 0.05和P< 0.01)。治疗4周末，观察组有效率为90.0%，明显高于对照组的74.4%(P< 0.05）；两组HAMA总分、SAS评分差异无统计学意义(P > 0.05)。对照组总不良反应发生率为44.2%高于观察组的42.0%，但差异无统计学意义（P＞0.05）。结论：加味酸枣仁汤联合帕罗西汀可以有效控制广泛性焦虑症患者的焦虑症状，在治疗1～3周可以达到快速起效的作用。 |
| 英文摘要: |
| ABSTRACT Objective:To investigation the efficacy and safety of modified Suanzaoren decoction with paroxetine for the treatment of generalized anxiety disorder (GAD) patients with yin deficiency and fire excess syndrome. Methods:104 GAD patients with yin deficiency and fire excess syndrome were randomly divided into two groups, treated with paroxetine or paroxetine combined with modified Suanzaoren decoction respectively for 4 weeks. HAMA and SAS tests were determined each week as the evaluation of clinical efficacy. The adverse drug reactions were observed by performing TESS test.Results:After 1 3 weeks treatment, HAMA, SAS scores and effective rate of the observation group was superior to the control group (P<0.05 or P< 0.01). After 4 weeks of treatment, the effective rate of the observation group was 90%, which was significantly higher than that of the control group 74.4%(P< 0.05）; There had no statistically significant difference between the two groups on the HAMA and SAS scores (P>0.05). The incidence rate of adverse reactions in control group was 44.2%, that in observation group was 42.0%, there was no statistical significance (P>0.05).Conclusion:Modified Suanzaoren decoction combined with paroxetine could effectively control anxiety symptoms in patients with generalized anxiety disorder, and could achieve rapid onset after 1 3 weeks treatment. |
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