| ABSTRACT Objective:To investigate the rules and the characteristics about adverse drug reactions happened in hospital of Xi’an area, and provide references for rational drug use in clinics. Methods:The Pareto optimal analysis was adopted to analyze the 2 076 cases of ADR reports from 2013 to 2015, including patients' age, drug varieties, antibacterial varieties, pharmaceutic preparation, routes of administration, and clinical manifestations. Results:The vital few factors of patients’ age which induce the 2 076 ADRs were 0 10 (16.81%), 51 60 (16.81%), 61 70 (13.34%), 71 80 (12.24%), 21 30 (11.27%) and 41 50 (10.31%). The vital few factors of drug categories were anti infective agents (46.97%), traditional Chinese medicine injection (14.40%), central nervous system drugs (9.34%), vitamins, nutrition drugs, enzyme preparation and balance water, electrolyte and acid base balance drugs (8.14%), in anti infective agent, cephalosporins accounted for the highest (35.79%). The vital few factors of administration route and pharmaceutic preparation were intravenous drip (85.84%) and injection(88.05%). The main clinical manifestations were the skin and its appendages damage (41.43%), alimentary system lesion (14.92%), systemic damage (13.49%) and nervous system damage (10.75%). Conclusion: In order to reduce the incidence of ADR, the rational drug use should be mastered, the safeguard should be strengthened and effective measures should be taken to monitor and manage ADRs. |
