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| 93例结直肠癌患者化疗后骨髓抑制情况分析 |
| Analysis of Bone Marrow Depression after Chemotherapy in 93 Patients with Colorectal Cancer |
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| DOI： |
| 中文关键词: 结直肠癌 化疗 骨髓抑制 |
| 英文关键词:Colorectal cancer Chemotherapy Bone marrow depression |
| 基金项目:德阳市2014年度应用技术研究与开发资金计划项目（编号：2014SZ097-2） |
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| 中文摘要: |
| 摘 要 目的：对我院93例结直肠癌患者4种化疗方案化疗后骨髓抑制发生情况进行回顾分析，为临床安全用药提供参考。方法：收集整理我院2014年4月～2015年3月共93例结直肠癌患者化疗后的骨髓抑制发生情况，根据患者情况及化疗方案分析其发生特点及影响因素。结果：93例结直肠患者经化疗后，发生骨髓抑制39例（41.94%），其中重度骨髓抑制为7例（17.95%）；骨髓抑制发生时间主要集中在化疗后1～2周内；不同性别、年龄患者骨髓抑制构成比差异无统计学意义；多药联合化疗所致的骨髓抑制发生率（50%）较单药（27.27%）高，差异有统计学意义（P＜0.05）。结论：化疗方案与患者发生骨髓抑制概率密切相关。因此，临床医生与药师应慎重选择化疗方案，密切监测骨髓抑制发生时间，采取积极措施降低骨髓抑制的发生风险，促进患者用药安全。 |
| 英文摘要: |
| ABSTRACT Objective:In our hospital 93 cases of colorectal cancer patients with four chemotherapy regimens happened bone marrow depression after chemotherapy were analyzed, and provide reference for clinical medication safety. Methods:Collected from April 2014 to March 2015 a total of 93 cases of colorectal cancer after chemotherapy in patients with bone marrow suppression, according to the situation of patients and chemotherapy regimens to analyze its characteristics and influence factors. Results:93 patients with colorectal after chemotherapy, bone marrow depression of 39 cases (41.94%), severe bone marrow depression of the 7 cases (17.95%). Bone marrow depression occurred mainly in 1 to 2 weeks after chemotherapy. There was no statistically significant difference incidence of bone marrow depression with gender and age. The incidence of bone marrow depression caused by multi drug combination chemotherapy is higher than single agent chemotherapy. The difference was statistically significant (P<0.05).Conclusion:Chemotherapy regimens was closely related to the probability of bone marrow depression in patients. Therefore, clinical doctors and pharmacists should carefully choose chemotherapy regimens, close monitoring of bone marrow depression occurred, to take active measures to reduce the risk of bone marrow depression, promote patients medication safety. |
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