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| 亚胺培南/西司他丁对1 372例患者肝功能的影响 |
| Influence of Imipenem cilastin on 1 372 Patients’ Liver Function |
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| DOI： |
| 中文关键词: 亚胺培南/西司他丁 住院患者 肝功能异常 |
| 英文关键词:Imipenem cilastin Inpatient Abnormal liver function |
| 基金项目:国家自然科学基金项目（编号：81403170） |
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| 中文摘要: |
| 摘 要 目的：调查某三甲医院住院患者使用注射用亚胺培南/西司他丁后发生肝功能异常的病例，为提高该药用药安全性提供依据。方法：调取该院2016年2月~2017年1月使用亚胺培南/西司他丁住院患者病历1 372份，对患者基本信息、药物使用情况及用药期间肝功能指标等进行统计分析。结果：1 372例静滴正常剂量亚胺培南/西司他丁的患者连续给药（6.29±3.99）d后，28例患者发生肝功能异常[AST（102.96±43.74） U·L-1，ALT（131.79±74.03） U·L-1]，发生率为2.04%；停用亚胺培南/西司他丁5~6 d后患者肝功能基本恢复正常；用药期间患者血清胆红素含量均在正常水平。结论：亚胺培南/西司他丁导致的肝功能异常为常见急性肝细胞损伤型药物性肝损伤，其损伤程度较轻且可逆，但依然应引起医生和药师关注。 |
| 英文摘要: |
| ABSTRACT Objective:To investigate the inpatients of liver dysfunction induced by imipenem cilastin for promoting the rational use of it.Methods:The inpatients cases using imipenem cilastin from February 2016 to January 2017 were gathered, and the basic information, drug use and liver function of inpatients were statistic analyzed. Results:1 372 inpatients were intravenously dripped imipenem cilastin for (6.29±3.99)d, 28 inpatients occurred liver dysfunction [AST (102.96±43.74)U·L-1, ALT (131.79±74.03)U·L-1]. The incidence rate was 2.04%. The liver function was recovered after stop using imipenem cilastin 5 6d. While, the levels of serum bilirubin were normal during the administration.Conclusion:The liver dysfunction induced by imipenem cilastin was acute liver cell damage type of drug induced liver injury, which was reversible and slight. However, doctor and pharmacist should pay attention. |
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