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| 国内部分医院β-内酰胺类抗生素皮肤试验现状调查分析 |
| Current Practice of Skin Testing for Beta lactams in Chinese Hospitals |
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| DOI： |
| 中文关键词: β-内酰胺类抗生素 皮肤试验 交叉过敏反应 问卷调查 |
| 英文关键词:Beta lactams Skin testing Cross allergic reaction Questionnaire |
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| 中文摘要: |
| 摘 要 目的：采用问卷调查了解并分析我国医院β-内酰胺类抗生素皮肤试验的实际操作情况。方法：通过电子邮件或传真方式对国内100家医院的临床药师进行问卷调查。问卷内容涵盖医院的名称、级别；β-内酰胺类药物皮肤试验方法，包括皮试液的来源和浓度、操作方法、观察时间、阳性结果的判定标准；涉及过敏史时，β-内酰胺类药物的皮肤试验以及针对口服青霉素制剂是否需要皮肤试验等14个方面的相关问题。结果：共收到信息完整的反馈问卷80份（反馈比80%）。调查显示各医院β-内酰胺类药物皮肤试验流程各有不同。不同医院在抗生素皮试品种、皮试方法、涉及过敏史时药物的选择以及口服青霉素制剂是否进行皮试等方面均存在明显差异。结论：本研究反映了现阶段我国医疗机构在β-内酰胺类抗生素皮肤试验方面缺乏统一标准，亟需尽快出台相关临床指南或共识，以保证临床使用该类药物的安全性与规范性。 |
| 英文摘要: |
| ABSTRACT Objective:This study was designed to investigate the current practice of skin testing (ST) for beta lactams in Chinese hospitals and discuss the potential problems by questionnaires. Methods:A fourteen question questionnaire was sent to one hundred hospitals which employed professional clinical pharmacists in Mainland China and then collected back via e mail or fax. The questions included the information of hospitals, detail information of ST practice, the clinical choices for patients who had an allergic history of beta lactams and also the concerns of ST for oral penicillin preparation. Results:The total response rate was 80%. The current practice of ST for beta lactams performed in Chinese hospitals differed with regard to the technique, reagent, test concentration, injection volume and positive criterion. The respondents’ attitudes for patients’ allergic history and oral penicillin preparation testing were also inconsistent and varied. Conclusion:There was still a lack of unified standard of ST for beta lactams in Chinese Hospitals. This survey highlighted an urgent need for national guideline or consensus of ST for beta lactams to increase using safety and normativity for these antibiotics in China. |
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