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| 临床药师对1例头孢他啶致中性粒细胞缺乏病例的治疗干预 |
| Insight into the Pharmaceutical Care: How to Deal with Agranulocytosis Caused by Ceftazidime |
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| DOI： |
| 中文关键词: 头孢他啶 中性粒细胞缺乏 白细胞减少 发热 |
| 英文关键词:Ceftazidime Agranulocytosis Leukopenia Fever |
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| 中文摘要: |
| 摘 要1例30岁男性患者因皮肤软组织感染，给予头孢他啶2 g，ivd，bid，用药21 d后出现发热、咽痛症状，血常规示白细胞计数（WBC）1.3×109·L-1、中性粒细胞绝对数（NEUT）0.4×109·L-1，管床医师要求临床药师介入，临床药师建议停用头孢他啶，给予地榆升白片0.2 g，po，tid。停药第2 d复查血常规：WBC 2.5×109·L-1、NEUT 0.28×109·L-1，给予万古霉素0.5 g，ivd，q8h、重组人粒细胞刺激因子注射液300 μg，ih，qd。停药第3日，患者体温恢复正常，WBC 8.9×109·L-1、NEUT 5.71×109·L-1。患者出院后1年内随访血常规均正常。 |
| 英文摘要: |
| ABSTRACTA 30 old male patient was given Ceftazidime 2 g twice daily for skin soft tissue infection, he developed a high fever and and his white blood cells count (WBC) was 1.3×109·L-1 and neutrophil count (NEUT) was 0.4×109·L-1 twenty one days later. The doctor asked advice from us clinical pharmacists, we suggested to stop Ceftazidime and give Diyushengbai tablet 0.2 g thrice daily, these opinions were adopted. Two days later, the WBC was 2.5×109·L-1 and the NEUT was 0.28×109·L-1，Vancomycin 0.5 g thrice daily and Recombinant Human Granulocyte Stimulation Factor Injection 300 μg once daily were given. Three days after withdrawal, his temperature was normal, the WBC was 8.9×109·L-1 and the NEUT was 5.71×109·L-1. During the year out of hospital, his WBC and NEUT were both within normal limits. |
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