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| 鸦胆子油乳协同周剂量TX方案治疗晚期胃癌的疗效研究 |
| Effects of Brucea Javanica Oil Combined with Chemotherapy of Weekly TX Regimen in Treating Patients with Advanced Gastric Cancer |
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| DOI： |
| 中文关键词: 晚期胃癌 鸦胆子油乳注射液 周剂量TX方案 化疗 |
| 英文关键词:Advanced gastric cancer Brucea Javanica Oil injection Weekly TX regimen Chemotherapy |
| 基金项目:2014年浙江省中西医结合学会临床药学科研基金项目（编号：2014LYK021）；2016年浙江省医药卫生一般研究计划项目（编号：2016KYB036） |
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| 中文摘要: |
| 摘 要 目的：评价鸦胆子油乳注射液协同周剂量TX方案治疗晚期胃癌的临床疗效。方法：42例晚期胃癌患者随机分为观察组（给予鸦胆子油乳注射液联合周剂量用剂量TX方案）19例和对照组（给予单纯周剂量TX方案化疗）23例。入组患者均至少接受2个周期以上的化疗。观察比较两组近期疗效、生活质量和生存期。结果：观察组近期有效率为63.2%，显著高于对照组的8.7%(P<0.05)；观察组疾病控制率为94.7%，对照组为87.0%，差异无统计学意义( P>0.05)。观察组中位生存时间为741 d，显著高于对照组的359 d( P<0.05)。 结论：鸦胆子油乳注射液联合周剂量TX方案治疗晚期胃癌可明显提高患者化疗的近期疗效，延长患者的生存期。 |
| 英文摘要: |
| ABSTRACT Objective:To evaluate the efficacy of Brucea Javanica Oil injection in association with weekly TX regimen in curing patients with advanced gastric cancer. Methods:42 patients with confirmed diagnosis of advanced gastric cancer were assigned to treatment group (Brucea Javanica Oil injection treatment combined with chemotherapy of weekly TX regimen, n=19) and control group(chemotherapy of TX regimen, n=23). All eligible patients received two cycles chemotherapy at least, and the recent curative effect and quality of life and survival were observed. Results: The response rate of treatment and control group were 63.2% and 8.7%, there were significant differences between two groups (P<0.05); the disease control rate of treatment and control group were 94.7% and 87.0% (P>0.05). The media survival time of treatment and control group were 741 days and 359 days, there were significant differences between two groups (P<0.05).Conclusion:Brucea Javanica Oil injection could not only improve the short term effect of weekly TX regimen, but also pro long the overall survival time of advanced gastric cancer patients. |
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