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| 144例药物性肝损伤住院患者的回顾性分析 |
| Retrospective Analysis of 144 Inpatients with Drug induced Liver Injury |
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| DOI： |
| 中文关键词: 药物性肝损伤 药物流行病学 保肝药 |
| 英文关键词:Drug induced liver injury Pharmacoepidemiology Hepatoprotective drugs |
| 基金项目:上海市药学会上海医院药学科研项目（编号：2017-YY-02-13） |
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| 中文摘要: |
| 摘 要 目的：了解长海医院住院患者中药物性肝损伤（DILI）病例的流行病学特点，及保肝药临床使用情况。方法：收集该院2016年全年确诊为DILI的病历资料，回顾性分析DILI与年龄、性别及药物的相关性，以及患者保肝药联合用药方案及保肝药的使用情况。结果：共收集到144例DILI患者，其中女性多于男性，45～65岁年龄段的患者构成比最高。导致DILI的药物有14类，中草药和中成药占54%，西药占46%。保肝药不合理使用较为明显，尤其是保肝药联合给药方案。结论：针对DILI的治疗，应在指南及循证医学证据的指导下，结合患者病情，制订个体化治疗方案，合理使用保肝药。 |
| 英文摘要: |
| ABSTRACT Objective:To investigate the epidemiological characteristics of drug induced liver injury (DILI) and the clinical application status of hepatoprotective drugs in inpatients in Shanghai Changhai Hospital. Methods:Cases with DILI were collected from this hospital in 2016. Retrospective analysis was conducted on the correlation between DILI and age, sex and drugs, and the combined dosage regimens of hepatoprotective drugs and the use of hepatoprotective drugs were analyzed.Results:There were totally 144 DILI cases. More women than men. The proportion of patients aged 45 65 years was the highest; There were 14 kinds of drugs induced DILI. 54% were Chinese herbal medicine and Chinese patent medicine, and 46% were western medicine. Irrational application of hepatoprotective drugs were obvious, especially the combined dosage regimen of hepatoprotective drugs. 〖WTHZ〗Conclusion:〖WTBZ〗It was important to promote rational use of hepatoprotective drugs for drug induced liver injury, the individualized treatment should be formulated in combination with the patient's condition. |
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