| ABSTRACT Objective:Understanding the trend of drug resistance of Acinetobacter baumannii to provide the basis of experiential therapy for clinic. Methods:Retrospective analysis was used for Acinetobacter baumannii isolated during 2011 to 2015 in Shandong provincial hospital. The change trend of the drug susceptibility and the drug susceptibility of isolates from different parts. Results:From 2011 to 2015, a total 1355 strains Acinetobacter baumannii were isolated,mainly distributed in sputum, skin and soft tissues, catheter, urine and cerebrospinal fluid. Non ICU isolates were 67.23%. Imipenem resistant Acinetobacter baumannii was 53.5%, and the antibiotic sensitive rates to tigecycline and polymyxin were higher, which more than 90%. The antibiotic sensitive rates to other antibiotic were less than 70%. During 14 antibacterial agents, there were 11 drug susceptibility elevated significantly, when compared 2012 with 2011, 2013 with 2012. However, the drug susceptibility results did not change significantly when compared 2014 with 2013, and the drug susceptibility results decreased significantly when compared 2015 with 2014. The strains from different parts showed different drug susceptibility. For carbapenem resistance Acinetobacter baumanniihe sensitive rates of all antibiotic but tigecycline and polymyxin were less than 30%, which ignificantly lower than the arbapenem sensitive Acinetobacter baumannii. Conclusion:The infection of Acinetobacter baumannii may spread and we should prevent and control the infection in hospital. Most of Acinetobacter baumannii were isolated from clinic. It is very limited to choice in the clinical treatment. Clinicians should carefully choose antibiotics according to the results of the drug susceptibility. |
