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| 羟考酮不良反应的国内文献分析 |
| Literature Analysis on Adverse Drug Reactions caused by Oxycodone in China |
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| DOI： |
| 中文关键词: 羟考酮 药品不良反应 文献分析 安全用药 |
| 英文关键词:Oxycodone Adverse drug reaction Literature analysis Drug safety |
| 基金项目:湖北省自然科学基金面上项目（编号：2016CFB678） |
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| 中文摘要: |
| 摘 要 目的：了解近10年来羟考酮不良反应（ADR）的特点和相关因素，为临床安全用药提供参考。方法：检索中国知网 （CNKI）、维普医药信息咨询系统和万方数据库2007～2016年收录的羟考酮临床队列研究文献，采用 Excel软件分析羟考酮引起ADR发生的相关因素，分别从临床表现、给药途径及用药疗程三个方面进行分析。结果：共纳入羟考酮队列研究55篇，其中单药治疗46篇，联合用药9篇。羟考酮单药治疗诱发的ADR频次最高的是便秘45.87%，之后依次为恶心呕吐 34.22%、头晕头痛14.93%、嗜睡 8.03%等。除便秘外，其他ADRs均可随用药疗程增加而逐渐耐受。同时本文也收集到严重ADR（呼吸抑制）10例以及新的ADR（骨髓抑制和肝损）17例。此外，本文分析发现纳肛给药的ADRs发生率明显低于口服和静注，而联合用药后ADR发生频次均低于单药治疗。结论：临床应重视羟考酮引起的ADR，警惕严重ADR的发生，确保安全用药。 |
| 英文摘要: |
| ABSTRACT Objective:To explore the characteristics and the related factors of adverse drug reaction (ADR) caused by oxycodone, provide the support of drug rational use to clinic. Methods:CNKI, VIP medical information consulting system and Wanfang database from 2007 2016 were searched for studied about oxycodone related ADR. Analysis was performed by Excel software and conducted in respect of route of administration, course of treatment and appearance of ADRs involved. Results:A total of 55 cohort studies including oxycodone monotherapy 46 and combination 9. The highest frequency ADR induced by oxycodone monotherapy was constipation (45.87%), and then nausea (34.22%), vomiting (14.93%) and dizziness (8.03%). The ADRs can be gradually toleranced with the longer medical course, but except constipation. Severe ADRs (respiratory depression) 10 cases and new ADRs (bone marrow suppression and liver damage) 17 cases were collected. We also found that the lower ADRs incidence induced by oxycodone monothreapy in anus treatment, so does the combination treatment to monotherapy. Conclusion:Clinical attention should be payed to the ADRs of oxycodone to alert incidence of serious ADRs and ensure drug safety. |
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