| ABSTRACT Objective:To study the characteristics of adverse drug reactions (ADR) in a hospital of Xuzhou, and to provide some reference for clinical rational drug use. Methods: ADR reports were collected from 2005 to 2016, and retrospective method was used to analysis their characteristics according to age, sex, drug type and so on.Results:1 356 ADR cases were reported in past twelve years and the number of ADR reported varied from 18 cases to 274 cases per year. Among the 1 356 ADR cases, 679 cases were male (50.1%), and mean age was (36.4±26.1) years. The vast majority of ADR cases were general adverse reactions (86.2%), and caused by intravenous infusion (81.9%) and by a single drug (76.8%). ADR mainly involved the digestive system (22.8%) and skin and its accessories (21.6%). ADRs were most initiated by antimicrobials (55.6%), and followed by Chinese patent drug (10.0%) and antineoplastic agents (7.1%). Among antimicrobials, the most common drugs were quinolones (29.9%), β lactam (27.2%) and macrolides (22.5%). Azithromycin, levofloxacin, and gatifloxacin were the top three suspected drugs. Conclusion:In this hospital, ADRs were mainly caused by antimicrobials, Chinese patent drugs and antineoplastic agents. The management of these drugs should be strengthened and ADR monitoring should be actively carried out. It should improve the enthusiasm of medical personnel to report ADR. All those would promote clinical drug safety. |
