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| 基于Meta分析的舒血宁注射液对比丹参类注射液治疗冠心病心绞痛临床评价研究 |
| Meta analysis of Efficacy of Shuxuening Injection versus Radix Salviae Miltiorrhizae Injectable Preparations in the Treatment of Angina Pectoris |
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| DOI： |
| 中文关键词: 舒血宁注射液 丹参类注射液 冠心病心绞痛 Meta分析 |
| 英文关键词:Shuxuening injection Radix Salviae Miltiorrhizae injectable preparations Angina pectoris Meta analysis |
| 基金项目:国家自然科学基金项目(编号：81473547、81673829) |
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| 中文摘要: |
| 摘 要 目的：采用Meta分析方法评价舒血宁注射液对比丹参类注射液治疗冠心病心绞痛的有效性及安全性。方法：计算机检索the Cochrane Library、PubMed、Embase、SinoMed、中国知网、维普期刊数据库和万方数据库有关舒血宁注射液对比丹参类注射液治疗冠心病心绞痛的随机对照试验（RCTs），检索时限为各数据库建库至2017年3月。采用Cochrane风险评价表评价纳入研究的偏倚风险，提取资料通过RevMan 5.3软件进行Meta分析。结果：共纳入11个RCTs，累计1 057名患者。Meta分析结果显示，与丹参类注射液治疗相比,舒血宁注射液治疗冠心病心绞痛可提高心绞痛总有效率（RR=1.21，95%CI：1.14~1.28，P<0.01）和心电图总有效率（RR=1.33，95%CI：1.19~1.49，P<0.01），改善血液流变学指标和血脂指标。有3篇文献明确无不良反应，3篇文献报道了共7例不良反应，其他文献均未对安全性做出说明，无严重不良反应。结论：现有证据表明，舒血宁注射液治疗冠心病心绞痛在心绞痛总有效率、心电图总有效率、血液流变学及血脂指标改善等方面比丹参类注射液的疗效好。但基于现有RCTs的缺陷，所获得的支持证据强度有待提高，尚需要更多设计严谨、随访时间更长的临床研究予以证实。 |
| 英文摘要: |
| ABSTRACT Objective: To systematically evaluate the effectiveness and safety of Shuxuening injection (SXN) versus Radix Salviae Miltiorrhizae injectable preparations in treating patients with angina pectoris (AP). Methods:Randomized controlled trials(RCTs) regarding AP treated by SXN (experimental group) and Radix Salviae Miltiorrhizae injectable preparations (control group) were searched in the China National Knowledge Infrastructure Database, Wanfang Database, the Chinese Scientific Journals Database, the Cochrane Library, PubMed, Embase and SinoMed up to March, 2017. Two reviewers independently retrieved RCTs and extracted information. The Cochrane risk of bias method was used to assess the quality of included studies, and Meta analysis was conducted with RevMan 5.3 software. Results:11 studies involving 1 057 participants were included. Meta analysis, the results of experimental group was significantly superior to the control group in the total effective rate (RR=1.21, 95%CI：1.14 1.28, P<0.01), the total effective rate of electrocardiogram (RR=1.33, 95%CI：1.19 1.49, P<0.01), and the index of hemorheology and blood lipid. 3 articles cleared that there was no adverse drug reactions(ADRs) in the studies, 3 studies reported 7 ADRs. Conclusion:SXN was more effectiveness on AP than the control group. But based on the limitations of the study, rigorous design with long follow up clinical trials are necessary for further evidence. |
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