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| 4种水飞蓟素类药物治疗慢性乙型肝炎肝损伤的成本-效果分析 |
| Cost effectiveness Analysis of Four Silymarin Drug in the Treatment of Chronic Hepatitis B with Liver Damage |
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| DOI： |
| 中文关键词: 水飞蓟素 慢性乙型肝炎 成本 效果分析 药物经济学 |
| 英文关键词:Silymarin drug Chronic hepatitis B Cost effectiveness analysis Pharmacoeconomics |
| 基金项目:南京药学会-常州四药医院药学科研基金项目（编号：2014YX010） |
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| 中文摘要: |
| 摘 要 目的：研究4种水飞蓟素类药物治疗慢性乙型肝炎肝损伤的疗效和经济成本。方法：慢性乙型肝炎门诊患者144例随机分为水飞蓟素片组（A组），复方益肝灵胶囊组（B组），水飞蓟宾葡甲胺片组（C组），当飞利肝宁胶囊组（D组），每组36例。观察各组患者用药4周前后ALT、AST等生化指标，统计各组治疗总有效率，计算疗程费用、药物成本 效果（C/E）及敏感度分析。结果：4组治疗总有效率分别为72.22%、75.00%、61.11%和77.78%，差异无统计学意义（P>0.05）。4组C/E值分别为2.33，2.89，3.01和3.49，A组的C/E值最低，A组为最优治疗方案。最小成本敏感度分析与C/E结果一致。结论：水飞蓟素片为治疗慢性乙型肝炎肝损伤较为有效、经济的药物，在实际治疗过程中仍需根据患者的实际情况合理选择药物。 |
| 英文摘要: |
| ABSTRACT Objective:To study the clinical efficacy and economic cost of four silymarin drug in the treatment of chronic hepatitis B (CHB) with liver damage.Methods:114 patients with CHB in outpatient department divided randomly into Silymarin tablet group(group A), Fufang Yiganlin capsule group(group B), Silybin Meglumine group(group C) and Dangfei Liganning capsule group(group D), each had 36 patients. Serum ALT, AST test were carried out to compare the effective rate among the four groups at 4 weeks after drug treatment. And treatment costs, cost effectiveness ratio (C/E) and sensitivity analysis were also evaluated. Results:The total effective rate of four groups were 72.22%, 75.00%, 61.11% and 72.22%, respectively. There were no significant differences between each groups (P>0.05). The C/E value of each group was 2.33, 2.89, 3.01 and 3.49, respectively, which demonstrated that group A was lowest. Group A was the optimal therapeutic schedule. The results of minimum sensitivity analysis was as same as C/E analysis.Conclusion: Silymarin tablet was an effective and economic drug for the treatment of CHB with liver damage. And we still needed to choose a rational drug according to the actual situation in the treatment process. |
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