| ABSTRACT Objective:To assess the occupational exposure of chemotherapy drugs in Shanxi province by monitoring the residuesof chemotherapy drugs on different environmental surfaces, and to provide the basis for drug risk management in government departments and medical institutions.Methods:Environmental monitoring was carried out in ten hospitals in Shanxi province. Cyclophosphamide and cisplatin were chosen as monitoring markers.Five hospitals which have established pharmacy intravenous admixture services (PIVAS)chemotherapy drugs were assigned as PIVAS group. Five hospitals with oncology medical ward but no PIVAS were assigned as oncology medical group. Using an area of 2 cm × 2 cm filter paper to wipe samples (wipe area: 10 cm × 10 cm) from different sampling points (operating table, floor, medicine rack, trolley, refrigerator door handle, medicine basket, medicine chest, telephone and inside surfaces of gloves and masks). Determine the content of cyclophosphamide and cisplatin in these samples by high performance liquid chromatography. Results:The detection rate and total amount of cyclophosphamide and cisplatinin on cology medical group were signifi cantly higher than those in PIVAS group. The difference was statistically significant (P<0.05).From a distribution of contamination perspective, the total amount of cyclophosphamide and cisplatinin most of the wiping sites was significantly higher in oncology medical group than in the PIVAS group, and the largest difference was observed on operating table. In taking different protective measures, the detection rate of chemotherapy drugs in oncology medical group wearing one layer of gloves and one layer of mask was significantly higher than PIVAS group. In PIVAS group, the detection rate of disposable masks was significantly higher than N95 masks.Conclusion:Chemotherapy drugs have different degrees of contamination in different preparation environments, so it is necessary to enhance the monitoring and prevention of occupational exposure for chemotherapy drugs. |
