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| 基于关联规则的参麦注射剂不良反应流行病学特点研究 |
| Study on the Epidemiological Characteristics of Adverse Reaction Caused by Shenmai Injection Based on Association Analysis |
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| DOI： |
| 中文关键词: 参麦注射剂 数据挖掘 药品不良反应 关联规则 |
| 英文关键词:Shenmai injection Data mining Adverse drug reactions Apriori algorithm |
| 基金项目:国家自然科学基金项目(编号:81473547、81673829) |
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| 中文摘要: |
| 摘 要 目的：探索参麦注射剂不良反应（ADR）发生的流行病学特点。方法：通过系统检索1979~2015年文献，采集参麦注射剂ADR详细个案报告，在此基础上应用Microsoft ACCESS构建数据库，进而以Clementine 12.0为数据挖掘平台，应用关联规则Apriori算法开展数据挖掘研究。结果：共检索符合纳入条件的参麦注射剂ADR详细个案118例。其临床诊断大致有6类，呼吸系统损害20例（16.95%），皮肤及其附件损害19例（16.10%），全身性损害26例（22.03%），神经紊乱23例（19.49%），胃肠系统损害18例（15.25%），心率及心律紊乱12例（10.17%）。后项包含ADR诊断的关联规则有“ADR发生在0~5 min之内的男性患者占总体研究案例的14.41%，其中41.18%的患者的ADR诊断为全身性损害”。结论：参麦注射剂ADR诊断种类可能与患者性别、配液种类等因素相关，尚需更大样本量的数据分析验证。 |
| 英文摘要: |
| ABSTRACT Objective:To explore the epidemiological characteristics of Shenmai injection adverse reactions. Methods:Analysis the collected detail injection case reports from 1979 to 2015, apply Microsoft ACCESS database platform and Clementine 12.0 platform for data mining which include association rules Apriori algorithm. Results: 118 Shenmai injection adverse reaction cases were collected. There were about six kinds of clinical diagnosis. Respiratory damage accounted for 16.95 %; the damage to the skin and its accessories accounted for 16.10%; total body damage accounted for 22.03%; neurological disorders accounted for 19.49 percent; Gastrointestinal damage was 15.25%; heart rate and heart rhythm disorders accounted for 10.17 percent. The association rules of ADR diagnostic includes the following list: “Adverse reaction cases of male patients occurred in 0 5min accounted 14.41 percent of the total studied cases, and 41.18 percent of these cases with ADR diagnosed as systemic lesions.”Conclusion:Occurrence of Shenmai injection’s ADR may be related to such factors as the gender of patients and liquor types which complex under the action of performance still needs a larger sample size analysis of the data validation. |
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