| ABSTRACT Objective:To examine the factors associated with fever in patients who underwent endoscopic submucosal dissection (ESD) or endoscopic mucosal resection (EMR) for gastrointestinal lesions, and to provide valuable reference for rational use of antibiotics. Methods:A total of 109 patients who underwent ESD or EMR at endoscopy center were reviewed with retrospective study. The patients were devided into two groups based on the body temperature on the day after EMR/ESD: group A, body temperature <37℃; and group B, body temperature ≥37℃. The clinical data of the two groups were compared,including age, gender,tumor size, surgical mode, location, with or without prophylaxis with antibiotics,and inflammatory markers before and after the surgery.Results:There were significant differences between the two groups in tumor size and surgical mode (P<0.05). However there was no significant difference between the two groups in age, gender and location (P>0.05). The investigation revealed that patients who underwent ESD were prophylactically applied with antibiotics; The proportion of patients who underwent EMR given prophylactically antibiotics in group A and B had no significant difference (P>0.05). Whether or not antibiotics were used, The white blood cell counts in group A and B and all patients were dramatically increased than before surgary (P<0.05). While for the neutrophile granulocyte, there was no significantly change (P>0.05). Conclusion:This study indicated that post ESD and patients with large tumors were more likely to develop fever, and we concluded that use of routine prophylactic antibiotics to patients undergoing esophageal EMR was unnecessary because post EMR transient fever couldn’t be improved with empirical antibiotics in most cases. |
