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| 风湿性疾病患者营养状况对使用硫唑嘌呤所致血液学毒性的影响 |
| Effect of Nutritional Status on Hematological Toxicity in Rheumatological Patients Treated with Azathioprine |
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| DOI： |
| 中文关键词: 硫唑嘌呤 营养风险筛查 血液学毒性 |
| 英文关键词:Azathioprine Nutritional risk screening Hematological toxicity |
| 基金项目:福建省自然科学基金项目（编号：13171298）；福建医科大学启航基金（编号：2016QH086） |
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| 中文摘要: |
| 摘 要 目的：探讨风湿病患者营养状况对使用硫唑嘌呤所致血液学毒性的影响。方法：对70例硫唑嘌呤服用患者应用营养风险筛查2002（NRS2002）进行筛查，比较两组患者各项营养指标，根据结果将患者分为无营养风险组（NRS2002<3 分，n=48）和有营养风险组（NRS2002≥3 分，n=22），两组患者均给予硫唑嘌呤片50 mg，po，qd联用羟氯喹片0.2 g，po，bid，治疗3个月以上。观察两组患者血液学毒性发生情况。结果：无营养风险组患者前白蛋白、血红蛋白、淋巴细胞计数水平明显高于营养风险组（P <0.01）；无营养风险组骨髓抑制总发生率较有营养风险组明显降低（P<0.05）。结论：营养不良状况可能导致硫唑嘌呤服用患者血液学毒性发生，因此硫唑嘌呤治疗期间应加强患者营养干预。 |
| 英文摘要: |
| ABSTRACT Objective:To investigate the effect of nutritional status on hematological toxicity in rheumatological patients treated with azathioprine. Methods:70 cases of patients treated with azathioprine were assessed by nutritional risk screening scale (NRS2002) to evaluate their nutritional status, and these patients were stratified as “without nutritional risk”(n=48, NRS2002<3 points) or “with nutritional risk”(n=22, NRS2002≥3 points). Two groups were given AZA (50 mg, po, qd) combined with Hydroxychloroquine (0.2 g, po, bid) therapy, which were treated for more than 3 months. The hematological toxicity of two groups were compared. Results: The levels of prealbumin, hemoglobin and lymphocyte count in patients without nutritional risk were significantly higher than those with nutritional risk (P<0.01); the incidence of bone marrow suppression was lower in patients without nutritional risk compared to those with nutritional risk (P<0.05). Conclusion:Malnutrition may effect the incidence of hematological toxicity in patients treated with azathioprine, so nutritional interventions should be strengthened. |
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