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| 不同剂型桂枝葛根汤治疗颈性眩晕的疗效比较 |
| Comparison of Therapeutic Efficacy of Guizhi Pueraria Decoction with Different Dosage Forms on Cervical Vertigo |
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| DOI： |
| 中文关键词: 桂枝葛根汤 剂型 颈性眩晕 血流动力学 炎症因子 |
| 英文关键词:Guizhi Gegen decoction Different dosage forms Cervical vertigo Hemodynamics Inflammation |
| 基金项目:江苏省药学会 奥赛康医院药学基金项目（编号：201517）；连云港市科技发展计划项目（编号：ZD1508)；连云港市521高层次人才培养工程 |
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| 中文摘要: |
| 摘 要 目的：观察不同剂型桂枝葛根汤治疗颈性眩晕的疗效差异，并初步探讨其作用机制。方法：96例颈椎病患者随机分为饮片组、配方颗粒组和葛根定眩胶囊组各32例，分别采用桂枝葛根汤饮片、配方颗粒和葛根定眩胶囊治疗14 d，比较3组患者的疗效和治疗前后血流动力学指标变化，酶联免疫法测定3组患者治疗前后IL-6及IL 1β的表达。结果：3组总有效率比较，差异无统计学意义（P＞0.05）。治疗后3 组患者眩晕和头痛评分均较治疗前明显改善（P＜0.01），饮片组眩晕评分优于胶囊组（P＜0.05）。治疗后3组患者基底动脉和双侧椎动脉的Vs和Vm均较治疗前明显增加（P＜0.01)，且配方颗粒组和胶囊组椎动脉的Vm低于饮片组（P＜0.05或P＜0.01）。治疗后，饮片组和配方颗粒组血清IL 6水平较治疗前明显降低(P<0.05)，饮片组和胶囊组血清IL-1β水平较治疗前明显降低(P<0.05)；胶囊组血清IL-6水平显著高于其他两组(P<0.05)，饮片组血清IL 1β水平显著低于配方颗粒组和胶囊组(P<0.05)。结论：桂枝葛根汤三种剂型治疗颈性眩晕的总有效率相当，部分疗效指标饮片相比配方颗粒和胶囊更优。此作用可能与增加脑血流及抑制相关炎症因子IL-6及IL-1β的表达有一定关联。 |
| 英文摘要: |
| ABSTRACT Objective:To investigate the clinical effects of Guizhi Pueraria decoction with different dosage forms on cervical vertigo and its related mechanisms. Methods: According to the random number table method, ninety six patients with cervical spondylosis were randomly divided into three groups: decoction pieces group treated by Guizhi Pueraria decoction, granule group and capsule group treated by Gegen Dingxuan capsule, 32 in each group. The three groups were treated for 14 days. The curative effect and hemodynamic indexes were analyzed. The expressions of IL-6 and IL-1β in each group were determined by enzyme linked immunosorbent assay. Results:Comparing the overall efficacy of the three groups, there was no statistical significance among the three groups (P>0.05). The symptoms of dizziness and headache in the three groups after treatment were significantly improved compared with those before treatment (P<0.01). The degree of improvement in decoction pieces group was better than that of the capsule group (P<0.05). After treatment, the Vs and Vm of basilar artery and bilateral vertebral artery in the three groups were significantly increased compared with before treatment (P<0.01), Vm of vertebral artery in granules group and capsule group was lower than that of decoction pieces group (P<0.05 or P<0.01); After treatment, the level of IL 6 decreased significantly in the decoction pieces group and formula granule group comparing with before (P<0.05), the level of IL 1β decreased significantly in the decoction pieces group and capsule group comparing with before (P<0.05); The level of IL 6 in capsule group was superior to the other two groups, and the IL 1β level in the decoction pieces group was significant lower than the other two groups. Conclusion:The three different dosage forms of Guizhi Pueraria decoction on cervical vertigo had similar overall efficacy, the decoction pieces was superior to the granules and capsules in some effect index. This effect might be related to the increase of cerebral blood flow and the inhibition of the expression of related inflammatory cytokines IL 6 and IL 1β. |
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