| ABSTRACT Objective:To evaluate the efficacy and safety of dezocine combined with tramadol for patient controlled analgesia (PCA). Methods:The randomized controlled trials of dezocine combined with tramadol for PCA were gathered from PubMed, Web of science, Embase, The Cochrane Library, CNKI, WanFang Data, SinoMed and VIP database from January 1995 to December 2017. Two reviewers independently screened literature, extracted data and assessed qualified of included studies. Then, Meta analysis was performed by RevMan 5.3 software. Results:Thirteen trials comprising 939 patients were included in the Meta analysis. The results of Meta analyses showed that: ① as for visual analog scale (VAS) score, compared with the tramadol group, the combination group (dezocine combined with tramadol) had significant differences at 12h, 24h and 48h post operation; ② as for Ramsay sedation score, compared with the tramadol group, the ramsay score at 24h, 48h had significant differences when dezocine combined with tramadol [24h: WMD=-0.34, 95%CI(-0.54, -0.13); 48h: WMD=-0.21, 95%CI(-0.28, -0.13),P<0.05]; ③ there were significant differences in bruggrmann comfort scale of PCA at 48h post operation between the combined group and the single tramadol group [WMD=-0.08, 95%CI(-0.12, -0.03),P<0.01]; ④ as for adverse reaction in the combination group compared with the single tramadol group, nausea and vomiting, skin itching, respiratory depression, dizziness and headache and incidences of adverse reaction were significantly decreased. Conclusion:According to the domestic evidence, dezocine combined with tramadol for PCA could effectively alleviate postoperative pain compared with tramadol alone,and could be able to reduce the incindence of adverse reactions. |
