| ABSTRACT Objective:To investigate the risk factors of venous thromboembolism (VTE) and the use of anticoagulant in lung cancer patients. Methods:Through the hospital HIS system, lung cancer who combined with VTE and hospitalization from 2006 to 2016 were selected as the case group, take a retrospective investigation of the usage of anticoagulant, and take a matched case control study to explore the risk factors of VTE in lung cancer patients, in this study lung cancer patients without VTE in the same period and match with age and sex were selected as control group. Results:In lung cancer patients who complicated with VTE, the irrational use rate of anticoagulant drugs was 45.84%. Low Molecular Heparin was the most used anticoagulant drug. In univariate analysis, lung cancer patients with concurrent VTE were associated with pulmonary disease, lung cancer staging, length of hospital stay, WBC, RBC, D dimer, Caprini score, PT, APTT and Vascular endothelial inhibitor. In multivariate analysis, length of hospital stay, RBC and D dimer were the risk factors. Conclusion:Length of hospital stay more than 12 days, decreasing level of RBC, increasing level of D dimer could probably increase the risk of VTE in lung cancer patients, therefore proper attention should be paid to these factors in clinical practice and preventive measures should be taken to reduce the incidence of VTE. |
