| ABSTRACT Objective:To explore the general patterns and characteristics of sitagliptin related acute pancreatitis and provide a reference for clinical medication safety.Methods: Case reports of sitagliptin related acute pancreatitis were searched from domestic and foreign academic journals from 1978 to August 2017. Then literatures were screened as well as the extraction. Information such as gender, age, race, primary disease, dosage, course of the treatment, clinical feature, outcome, severity, associated disease, combined medication and history of pancreatitis were collected and statistically analyzed. Results: A total of 8 literatures were retrieved which included 11 cases. Among them, 7 cases were female and 4 cases were male. Patients in 50 to 60 years old were 8 cases, accounting for 72.73%. Caucasian patients were more. Of all 11 patients, 10 patients developed within one year of treatment. Dose, treatment time and history of pancreatitis had little to do with acute pancreatitis. But treatment time was positively correlated with severity. After withdrawal and symptomatic treatment, most patients improved to discharge, except one died. Conclusion:Sitagliptin related acute pancreatitis was rare, but could be severe. Doctors should pay attention to patients' age, comorbidities and combined medication in clinical, especially women, 50 to 60 years old, accompanied by hypertension, hyperlipidemia, or combined with statins lipid lowering drugs. Patients' symptoms should be monitored closely within one year of treatment in order to promptly identify acute pancreatitis. |
