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近3年我院重症医学科细菌检出及抗菌药物耐药率分析
Recent Three Years’ Bacteria Detections and Antibiotic Resistances of Department of Critical Care Medicine in Our Hospital
  
DOI:
中文关键词:  重症医学科  细菌  耐药率  抗菌药物
英文关键词:Department of critical care medicine  Bacteria  Drug resistances  Antimicrobial agent
基金项目:
作者单位
宋仕聪1 谢恒1 刘易林1 李莉1 陈伟娟2 粤北人民医院 1.重症医学科2.检验科 广东韶关 510000 
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中文摘要:
      摘 要 目的:对我院重症医学科近3年细菌检出结果和耐药率进行统计分析,为临床抗感染治疗提供参考。方法:收集2015~2017年粤北人民医院重症医学科所有检出细菌分离的菌株及药敏结果,统计分析该区域细菌流行趋势及耐药率变迁。结果:近3年共检出1 399株细菌,其中革兰阴性菌株1 021株(72.98%),革兰阳性菌378株(27.02%),多重耐药菌448株(32.02%)。鲍曼不动杆菌是检出率最高的细菌(25.16%),对碳青霉烯耐药严峻(>73.31%);肺炎克雷伯菌属(17.30%)近3年检出率呈上升趋势,对酶抑制药复合制剂和碳青霉烯类药物耐药率逐年增高;铜绿假单胞菌检出率排第3,检出率呈下降趋势;凝固酶阴性葡萄球菌、金黄色葡萄球菌和肺炎链球菌是检出率最高的革兰阳性菌,其中肺炎链球菌近3年检出趋势逐渐升高,3种细菌对青霉素耐药严重(>90%),暂未发现万古霉素、替考拉宁和利奈唑胺耐药菌。结论:我院重症医学科检出细菌以革兰阴性菌为主,抗菌药物耐药情况严峻,应结合本区域细菌流行趋势和耐药情况合理选用抗菌药物。
英文摘要:
      ABSTRACT Objective: To investigate the detections and drug resistances of the department of the critical care medicine in our hospital, so as to provide reference for treatment. Methods:The detections and drug susceptibility results of bacteria from the patients who had been admitted to the department of critical care medicine in our hospital between January 2015 and December 2017 were analyzed. Results:A total of 1 399 strains of bacteria were isolated durning the past three years, including 1 021 strains of gram negative bacteria (72.98%), 378 of gram positive bacteria (27.02%), among which, 448 strains of multidrug resistant organisms (MDROs) were isolated. Acinetobacter baumannii counted for the first place among the isolated bacteria (25.16%), and the antibiotic resistance rates to the carbapenems became higher and higher. The prevalence of Klebsiella pneumoniae (17.30%) counted for the second place and keep increasing durning the past three years, but the resistance to enzyme inhibitor complex and carbapenems keep climbing. Pseudomonas aeruginosa run for the third place, but the isolated rates keep decreasing in the past three years. The coagulase negative staphylococcus (CoNS), staphylococcus aureus and streptococcus pneumoniae were the first three bacteria isolated during the past three years while the isolated rates of streptococcus pneumoniae keep increasing. All of three had a serious resistance to penicillin (>90%) but no resistant stain to vancomycin, teicoplanin and linezolid was isolated. Conclusion:In the clinical work, we should choose a rational antimicrobial agent according to the bacteria distribution and drug resistance of the area.
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