| ABSTRACTDrug induced liver injury is one the cause of serious reactions during drug use and the main drug attrition during drug development and post marketing drug withdrawal. Biomarkers are important tools for evaluating preclinical drug hepatotocixity and clinical diagnosis of potential liver injury in patients. Due to the sensitivity, specificity and other factors, traditional indicators have limitations in the application of early evaluation. So discovery and verification of new biomarkers have imperatived. This paper summarizes the newly discovery liver injury biomarkers with scientific and clinical value from the new platform of modern science and technology. In order to better forecast hepatotoxicity of drugs, development trend, diagnosis the degree of liver damage, which could provide references for researchers, clinicians, new drug research and development institutions. |
