ABSTRACT Objective: Analyzing the rules and characteristics of adverse drug reaction / event (ADR/ADE) caused by opioids, to provide references for clinical drug use. Methods: Using retrospective studies, 972 cases of ADR/ADE reports collected by Hubei Center for ADR/ADE Monitoring from January 2007 to June 2018 were analyzed according to patients’ age and gender, occurrence time, the administration routes, clinical manifestations and prognosis, etc. Results:From the analysis of 972 cases of ADR/ADE reports of opioids, the ratio of male to female was 1 ∶1.20, and more ADR/ADE reports appeared in 51 70 age groups; the occurrence time of ADR/ADE cases mainly happened within 24 hours after the treatment(66.46%). The involved damages mainly contained gastrointestinal system disorders (38.96%), central and peripheral nervous system disorders (21.87%), skin and appendages disorders (10.46%), body as a whole general disorders (9.23%) and respiratory system disorders (4.51%). 10.49% of these cases were serious adverse effects. Intravenous injection (34.57%) and oral administration (32.51%) were the two routes of administration used more frequently in these cases. Conclusion:Opioids may cause multiple and serious ADR/ADE, therefore, more attention should be paid to the clinical use of opioids. And ADR/ADE monitoring should be strengthened to improve the safety of medication. |