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长沙市2016年抗感染药物所致新的严重的药品不良反应分析
Analysis of New and Serious Adverse Drug Reactions Associated with Anti infection Drugs in Changsha During 2016
  
DOI:
中文关键词:  抗感染药物  药品不良反应,新的,严重的  长沙市  合理用药  安全用药
英文关键词:Anti infection drugs  Adverse drug reactions, new, serious  Changsha  Rational drug use  Safe medication
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作者单位
孙吉1 何鸽飞1 陈志宏2陈恒1 刘晓慧1 张顺芝1 1.长沙市第一医院 长沙 4100052.长沙市食品药品监督管理局 
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中文摘要:
      摘 要 目的:了解长沙市2016年抗感染药物所致新的和严重的药品不良反应(ADR)的发生特点。方法:收集长沙市不良反应监测中心2016年收集到的340例抗感染药物所致新的和严重的ADR,采用回顾性分析方法,对ADR报告的一般情况、患者性别年龄、给药途径、涉及药物的类别及品种、ADR累及器官或系统、转归、关联性评价、不合理用药情况与转归等进行统计分析。结果:340例新的和严重的ADR中,年龄大于60岁的患者所占比例最大;静脉注射给药的患者数超过55%;ADR报告的99.12%来源于医疗机构;340例ADR共涉及14类药物,其中头孢菌素类所占比例最大,而抗结核药物所致严重ADR比例最大;ADR累及的器官或系统以全身损害居多,严重ADR中有130例(57.85%);340例ADR中存在不合理用药的有39例(11.47%),包括给药剂量过大、无适应证用药、药物选择不适宜、联合用药不合理、溶媒选择不适宜、给药频次不适宜、滴注速度不适宜等。结论:抗感染药物所致的ADR的发生与多种因素有关,临床应重视抗感染药物的合理应用,警惕可能由于抗感染药物的不合理使用而诱发的严重ADR。另外,在评价是否为新的ADR时,要严格按照标准评价,以保证数据的真实准确。
英文摘要:
      ABSTRACT Objective: To study the characteristics of new and serious ADR cases which associated with anti infection drugs in Changsha during 2016. Methods:340 ADR cases induced by anti infection drugs,which collected from Adverse Reaction Monitoring Center of Changsha in 2016 were retrospectively analyzed in terms of the general situation of ADR report, the sex and age of patients, the route of administration, the types and varieties of drugs involved, ADR involved organs or systems, outcome, correlation evaluation, unreasonable drug use and outcome. Results:of the 340 new and severe ADR caused by anti infective drugs, the proportion of patients older than 60 years was large. The patients with intravenous administration in the route of administration were more than 55%. 99.12% of ADR reports originated from medical institutions; 340 cases of new and severe ADR which induced by anti infective drugs, involving a total of 14 categories of drugs. The proportion of cephalosporins was the largest. And the proportion of severe ADR caused by anti TB drugs was the largest. ADR involved in the organ or system with the majority of systemic damage, serious ADR has 130 cases (57.85%). There were unreasonable drug problems in 39 cases, accounting for 11.47%, in which the primary cause was excessive doses, followed by no indication, inappropriate drug selection, unreasonable combination, inappropriate solvent selection, inappropriate dosing frequency and the infusion. Conclusion:Anti infection drugs induced ADR are related with many kinds of factors. It is very important to pay more attention to rational use anti infection drugs and to prevent serious ADR caused by unreasonable use of drugs. Furthermore, In the evaluation of the new ADR, it must be in strict accordance with standard evaluation and to ensure that the data is true and accurate.
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