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氨酚羟考酮对1 435例住院患者肝功能的影响
Influence of Aminophenol Oxycodone on 1 435 Inpatients’ Liver Function
  
DOI:
中文关键词:  氨酚羟考酮  肝损伤  药品不良反应  影响
英文关键词:Aminophenol oxycodone  Liver damage  Adverse drug reactions  Influence
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作者单位
潘雪芬1 陈志民1 艾建国2 解放军第180医院 1.药学科2.骨科 福建泉州 362000 
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中文摘要:
      摘 要 目的:探讨氨酚羟考酮对肝功能影响的特点,为提高用药安全提供依据。方法:调取我院2017年8月~2018年7月使用氨酚羟考酮片的住院患者病历共1 435份,对患者的基本资料、用药情况及肝功能指标等进行统计分析。 结果:1 435例患者中氨酚羟考酮致肝损伤20例,发生率为1.39%,其中以30~39岁和60~69岁患者居多。不同疼痛类型的患者中,头痛患者肝损伤的发生率最高(10.00%)。不同给药剂量方面,氨酚羟考酮给药剂量660mg qd患者肝损伤发生率最高(5.41%)。治疗时间1~3 d出现肝损伤的患者最多达9例。停药前,发生肝损伤患者的ALT、AST水平和AST/ALT值均明显高于治疗前(P<0.05),而总胆红素(TBil)、直接胆红素(DBil)和间接胆红素(IBil)较前未见明显变化(P>0.05)。经停药和对症治疗,1周后患者的血清转氨酶水平恢复正常(P>0.05)。结论:氨酚羟考酮致肝损伤属于肝细胞损伤型的药物性肝损伤,其症状较轻且可逆,但仍应引起临床的关注。
英文摘要:
      ABSTRACT Objective: To explore characteristics of influence of aminophenol oxycodone on liver function, and to provide evidence for improving drug safety. Methods:A total of 1 435 inpatients using aminophenol oxycodone tablets from August 2017 to July 2018 in our hospital were transferred. Then, patients' basic data, medication status and liver function indicators were statistically analyzed. Results:The incidence of liver damage caused by aminophenol oxycodone in 1 435 patients was only 1.39%. Among them, 30 to 39 years old and 60 to 69 years old patients were more. In 20 patients with liver injury, the incidence of liver injury in headache patients was the highest (10.00%) in different types of pain. The incidence of liver injury in patient treated by aminophenol oxycodone in 660 mg, qd was the highest in different administration dosages. 9 patients with liver damage occurred within 1 to 3 days of treatment. Before withdrawal, the levels of ALT, AST and AST/ALT in patients with liver damage were significantly higher than those before treatment, and the difference was statistically significant (P<0.05). However, there was no significant change in TBil, DBil and IBil, and the difference was not statistically significant (P>0.05). After one week of withdrawal and symptomatic treatment, the serum aminotransferase level of the patient returned to normal, and there was no significant difference compared with before treatment (P>0.05). Conclusion:Liver damage caused by aminophenol oxycodone is a drug induced liver injury of the type of hepatocyte injury. The symptoms are mild and reversible, but should still cause clinical attention.
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