| ABSTRACT Objective:To study the risk factors of adverse drug reaction (ADR) induced by moxifloxacin hydrochloride and sodium chloride injection, to provide some tips for the clinically safe and rational use of drugs. Methods: Data of 378 cases for all hospitalized patients used moxifloxacin hydrochloride and sodium chloride injection were retrospectively analyzed from January 2015 to June 2017. The gender, age, history of allergy, drug use, ADR of the patients were investigated. The risk factors were analyzed by multiple factors Logistic analysis. Results:In the 378 cases, 47 ADRs with incidence of 12.43%, among which 25 showed superinfection (6.61%), 10 showed allergic reactions (2.65%), 4 showed gastrointestinal reactions (1.06%), 4 showed nervous system reactions (1.06%), 3 showed cardiovascular system reactions (0.79%) and 1 showed hepatobiliary system reactions (0.26%). Logistic regression analysis showed duration (OR=1.579, P=0.007), coexistent chronic diseases (OR=4.188, P=0.043) and ALT (OR=1.080, P=0.030) were risk factors of ADR induced by moxifloxacin hydrochloride and sodium chloride injection.Conclusion:Long duration, coexistent chronic diseases and abnormal level of ALT are the possible rick factors that caused ADR induced by moxifloxacin hydrochloride and sodium chloride injection. Close observation and controlling duration should be noticed to reduce the incidence of adverse reactions for coexistent chronic diseases and abnormal level of ALT medication. |
