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| 宁神温胆汤治疗奥氮平所致代谢综合征观察 |
| Clinical Observation on Effect of the Treatment of Non typical Antipsychotics (Metabolic Syndrome) by Ningshenwendan Decoction |
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| DOI： |
| 中文关键词: 宁神温胆汤 代谢综合征 奥氮平 精神分裂症 |
| 英文关键词:Ningshenwendan Metabolic syndrome Olanzapine Schizophrenia |
| 基金项目:浙江省中医药科学研究基金项目（编号：2017ZA140） |
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| 中文摘要: |
| 摘 要 目的：观察宁神温胆汤治疗奥氮平所致代谢综合征的临床效果。方法：100例奥氮平所致代谢综合征患者随机分为观察组和对照组。对照组维持奥氮平原治疗方案不变，观察组在此基础上加用宁神温胆肠，两组疗程均6个月。比较两组患者治疗前，治疗8周末、24周末外周血清瘦素、血糖、胰岛素、脂联素水平和体重指数（BMI），观察记录两组患者治疗期间药品不良反应发生情况，以及治疗前，治疗8周末、24周末副反应量表（TESS）评分变化。结果：治疗8周末、24周末时对照组瘦素、血糖、胰岛素水平及BMI值均较前显著增加(P＜0.05)，脂联素水平较前明显下降(P＜0.05)；观察组各项指标与治疗前相比无明显差异(P＞0.05)；两组间比较，差异有统计学意义(P＜0.05)。两组患者治疗前和治疗8周、24周末的TESS评分未见明显变化(P＞0.05) 。观察组不良反应总发生率为20.0%,明显低于对照组(P＜0.05)。结论：宁神温胆汤可有效控制奥氮平所致代谢综合征患者的体重、瘦素、血糖、胰岛素的水平，且不增加药品不良反应。 |
| 英文摘要: |
| ABSTRACT Objective:To evaluate the clinical effect of the treatment of nontypical antipsychotics caused by Ningshenwendan decoction.Methods: The patients with metabolic syndrome caused by 100 psychotropic drugs were randomly divided into observation group and control group. The control group was treated with the unchanged dose of the original antipsychotic drug, the observation group was combined with Ningshenwendan decoction. The course of treatment was 6 months, and peripheral blood leptin, blood glucose, insulin, adiponectin and BMI were detected before and after the treatment on 8 weeks and 24 weeks respectively. The adverse drug reaction of the two groups were recorded and the symptom scale (TESS) of the treatment was evaluated to evaluate the efficacy and safety of the Ningshenwendan decoction.Results: The peripheral blood leptin, blood glucose, insulin and body mass index (BMI) of control group were all significantly increased than before at the end of 8 and 24 weeks after treatment, the adiponectin level was significantly decreased (P<0.05); there was no significant difference in the observation group compared with treatment before (P>0.05). There were statistical differences between the groups (P<0.05). Comparison of TESS score between the two groups, the difference was not statistically significant before and after treatment at 8 and 24 weeks timepoints (P>0.05).The total incidence of adverse reactions in the observation group was 20.0%, which was significantly lower than that in the controll group(P<0.05).Conclusion:The Ningshenwendan decoction could effectively control the antipsychotic drugs in patients with metabolic syndrome caused by body weight, leptin, blood glucose, insulin levels, it did not increase the original antipsychotic adverse drug reactions. |
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