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| 老年女性骨质疏松症患者服用阿仑膦酸钠的回顾性调查 |
| Retrospective Investigation on Alendronate Treatment in Elderly Osteoporosis Women |
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| DOI： |
| 中文关键词: 骨质疏松 阿仑膦酸钠 骨转换标志物 女性 老年 |
| 英文关键词:Osteoporosis Alendronate Bone turnover markers Women Aged |
| 基金项目:浙江省医药卫生平台重点资助项目（编号：2016ZDA002） |
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| 中文摘要: |
| 摘 要 目的：寻找提高老年女性骨质疏松症（OP）患者服用阿仑膦酸钠的治疗效果的方法。 方法：对48例曾服用阿仑膦酸钠的老年女性OP患者进行调查，并分析服用阿仑膦酸钠的持续时间与血清骨转换标志物（BTMs，包括I型胶原羧基端肽β特殊序列、总I型胶原氨基端前肽和N端骨钙素）的关系。 结果：老年女性OP患者服用阿仑膦酸钠的情况不容乐观，其中坚持服用阿仑膦酸钠（≥12月）者仅占33.33%；坚持服用阿仑膦酸钠（≥12月）的老年女性OP患者3个BTMs水平都明显低于未坚持（＜12月）服用的，差异有统计学意义（P＜0.01）。结论：加强OP防治知识的宣传，延长服用阿仑膦酸钠的时间，可能是提高老年女性OP患者临床治疗效果的重要方法。 |
| 英文摘要: |
| ABSTRACT Objective:To probe into the ways to improve clinic therapeutic effects of alendronate treatment in elderly osteoporosis women.Methods:A cross sectional survey was conducted in a cohort comprising a sample of 48 elderly osteoporosis women. All subjects underwent a questionnaire survey on the duration of alendronate treatment and measurement of bone turnover markers (BTMs, included lopeptide of type 1 collagen, N terminal propeptide of type I collagen and osteocalcin), and the relationships between the duration of alendronate treatment and BTMs were analyzed. Results:Out of 48 elderly osteoporosis women, 16(33.33%) patients had received alendronate treatment with a duration of 12 months and more. The levels of BTMs were significantly lower in elderly osteoporosis women who had persisted to accept alendronate treatment (≥12month) than those in patients with a duration less than 12 months (all P＜0.01). Conclusion:To strengthen patient education of osteoporosis knowledge, and to improve their adherence to alendronate treatment would help to improve clinic therapeutic effect in elderly osteoporosis women. |
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