| ABSTRACT Objective: To systematically evaluate the clinical efficacy and safety of Tanreqing injection combined with antibiotics in treatment of elderly community acquired pneumonia (CAP). Methods:Randomized controlled trials (RCTs) regarding CAP treated by Tanreqing injection combined with antibiotics were searched in CNKI, VIP, WanFang Data, SinoMed, PubMed, the Cochrane Library and Embase from inception to May 31st, 2018. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Meta analysis was performed by ReveMan 5.3 software. Results:There were 23 RCTs included, involving 2 207 participants. According to the Meta analysis, compared with antibiotics alone, Tanreqing injection combined with antibiotics could improve total effective rate (RR=1.16, 95%CI 1.12 to 1.19, P<0.000 01). Besides, Tanreqing injection combined with antibiotics could shorten the patients’ antifebrile time, the pulmonary rales disappeared time and the disappearance time of cough. What’s more, it could lower the level of CRP and WBC. As for the security, 8 articles reported that there were no adverse drug reactions (ADRs)/adverse drug events (ADEs) in the studies, 9 articles reported the details of ADRs. And the rest had no illustrations for it. Conclusion: Tanreqing injection combined with antibiotics is more effective than conventional medicine alone in treatment of CAP, the safety is good. However, it is still necessary with further study for safety of its compatibility with western medicine. |
