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| 注射用头孢哌酮钠/舒巴坦钠对住院患者肝功能影响的回顾性调查 |
| Retrospective Investigation of the Effects of Cefoperazone Sodium/Sulbactam Sodium on Liver Function in Inpatients |
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| DOI： |
| 中文关键词: 注射用头孢哌酮钠/舒巴坦钠 住院患者 肝功能 安全用药 |
| 英文关键词:Cefoperazone sodium/sulbactam sodium for injection Inpatient Liver function Safe medication |
| 基金项目:国家自然科学基金项目（编号：81503327） |
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| 中文摘要: |
| 摘 要 目的：了解住院患者使用注射用头孢哌酮钠/舒巴坦钠后发生肝功能异常的情况及其相关因素，为临床安全用药提供参考。方法：采用回顾性研究方法，调取某院2017年2月～2018年1月使用注射用头孢哌酮钠/舒巴坦钠住院患者病历，对患者信息、感染部位、药物使用情况及肝功能指标变化进行统计分析。 结果：729例患者静脉滴注正常剂量注射用头孢哌酮钠/舒巴坦钠，连续给药（8.4±7.0） d后11例患者出现肝功能异常[AST（125.9±58.6 ）U·L-1，ALT（173.0±110.2 ）U·L-1]，发生率为1.51%。不同年龄、感染部位和给药方案的患者肝功能异常发生率存在差异。停用注射用头孢哌酮钠/舒巴坦钠5～6 d后患者肝功能基本恢复正常；而给药期间及停药后1～6 d患者血清胆红素水平较给药前无明显变化。结论：注射用头孢哌酮钠/舒巴坦钠可以诱导急性肝细胞损伤型药物性肝损伤，其损伤程度较轻且可逆，但临床使用该药时依然要重视用药期间肝功能的监测, 以保障用药安全。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the inpatients’ liver dysfunction induced by cefoperazone sodium/sulbactam sodium and relevant factors, providing references of rational use of it. Methods:Retrospective study method was used, the patient cases of using cefoperazone sodium/sulbactam sodium for injection from February 2017 to January 2018 were selected. The patients information, infection site, drug use and liver function were statistical analyzed. Results:729 inpatients were intravenously dripped cefoperazone sodium/sulbactam sodium for (8.4±7.0) d，11 inpatients had abnormal liver functions [AST: (125.9±58.6) U·L-1, ALT: (173.0±110.2) U·L-1]. The incidence rate was 1.51%. There were differences in the incidence of abnormal liver function in patients of different ages, infection sites and drug administration schemes. After stop using cefoperazone sodium/sulbactam sodium 5 6 days, the liver function was recovered. Compared with before treatment, the serum bilirubin concentrations had no significant difference during the administration or 1 6 days after stopping. Conclusion:Cefoperazone sodium/sulbactam sodium for injection could induce the acute liver cell damage type of drug induced liver injury, which was reversible and slight. However, the liver function should be monitored during the administration for ensuring medication safety. |
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