欢迎访问药物流行病学杂志网站！

设为首页加入收藏

国家科技部中国科技论文统计源期刊

中国科技核心期刊

WHO西太平洋地区医学索引(WPRIM)收录期刊

湖北优秀期刊

《药物流行病学杂志》官方网站与投审稿系统变更通知<点击查看详情>

基于Meta分析的炎琥宁注射剂联合阿奇霉素治疗小儿支原体肺炎临床评价研究

Meta analysis of Yanhuning Injection Combined with Azithromycin in the Treatment of Mycoplasma Pneumoniae in Children

DOI：

中文关键词: 炎琥宁注射剂阿奇霉素支原体肺炎 Meta分析随机对照试验

英文关键词:Yanhuning injection Azithromycin Mycoplasma pneumoniae Meta analysis Randomized controlled trial

基金项目:国家自然科学基金项目(编号：81473547、81673829)

作者	单位
何欣段笑娇吴嘉瑞王旗星王凯欢	北京中医药大学北京 102488

摘要点击次数: 718

全文下载次数: 466

中文摘要:

摘要目的：采用Meta分析方法评价炎琥宁注射剂联合阿奇霉素治疗小儿支原体肺炎的有效性和安全性，为临床决策提供科学依据。方法：全面系统地检索PubMed、Embase、Cochrane Library（2018年5期）、SinoMed、CNKI、WanFang Data和VIP数据库，搜集关于炎琥宁注射剂联合阿奇霉素治疗小儿支原体肺炎的随机对照试验（RCTs），检索时限均为建库至2018年9月14日，由两位研究人员独立进行文献筛选、数据提取和偏倚风险评价后，采用RevMan 5.3软件进行Meta分析。 结果：共纳入35个RCTs，累计3 089例患儿。Meta分析结果显示，与仅用阿奇霉素治疗比较，炎琥宁注射剂联合阿奇霉素治疗小儿支原体肺炎可明显提高临床总有效率[RR=1.18，95%CI（1.15，1.21），P＜0.000 01]。此外，炎琥宁注射剂联合阿奇霉素治疗小儿支原体肺炎还可更好地缩短咳嗽消失时间[MD=-2.55，95%CI（-2.75，-2.34），P＜0.000 01]、肺部啰音消失时间[MD=-3.03，95%CI（-3.26，-2.80），P＜0.000 01]、体温恢复时间[SMD=-3.79，95%CI（-4.63，-2.95），P＜0.000 01]、X线胸片病灶消失时间[SMD=-4.92，95%CI（-6.25，-3.60），P＜0.000 01]、平均治愈时间[MD=-3.21，95%CI（-3.44，-2.98），P＜0.000 01]，同时也可更好降低肿瘤坏死因子含量[SMD=-1.66，95%CI（-2.87，-0.45），P=0.007]和白介素 6含量[SMD=-1.44，95%CI（-2.57，-0.32），P=0.01]。结论：当前证据表明炎琥宁注射剂联合阿奇霉素治疗小儿支原体肺炎在改善临床总有效率、临床症状指标等方面优于仅用阿奇霉素治疗，至于安全性，尚需更多高质量的研究予以支持。

英文摘要:

ABSTRACT Objective: To systematically evaluate the efficacy and safety of Yanhuning injection combined with azithromycin in the treatment of mycoplasma pneumoniae in children, and provide the scientific evidence for clinical decision. Methods:PubMed, Embase, Cochrane Library (Issue 5, 2018), Clinicaltrial.gov, SinoMed, CNKI, WanFang Data and VIP databases were electronically searched to collect randomized controlled trials (RCTs) of Yanhuning injection combined with azithromycin in the treatment of mycoplasma pneumoniae in children from inception to September 14, 2018. Two reviewers independently screened literatures, extracted data and assessed risk of bias of included studies. Then Meta analysis was performed by RevMan 5.3 software. Results:A total of 35 RCTs with 3 089 participants were included. The results of Meta analysis showed that: Yanhuning injection combined with azithromycin could achieve a better effect than azithromycin alone in respect of total effective rate (RR=1.18, 95%CI 1.15 to 1.21, P＜0.000 01). In addition, the effectiveness of Yanhuning injection combined with azithromycin was superior to the azithromycin alone in cough disappeared time (MD=-2.55, 95%CI -2.75 to -2.34, P＜0.000 01), lung rales disappeared time (MD=-3.03, 95%CI -3.26 to -2.80, P＜0.000 01), temperature recovery time (SMD=-3.79, 95%CI -4.63 to -2.95, P＜0.000 01), X ray disappeared time (SMD=-4.92, 95%CI -6.25 to -3.60, P＜0.000 01), average healing time (MD=-3.21, 95%CI -3.44 to -2.98, P＜0.000 01). Moreover, comparing with azithromycin alone, Yanhuning injection combined with azithromycin was more effective in decreasing the levels of tumor necrosis factor α (SMD=-1.66,95%CI：-2.87 to -0.45, P=0.007) and interleukin 6 (SMD=-1.44, 95%CI -2.57 to -0.32, P=0.01). Conclusion:The current evidence indicates Yanhuning injection combined with azithromycin is better than azithromycin alone in improving total effective rate and clinical symptoms in the treatment of mycoplasma pneumoniae in children. However, safety still needed for further studies.

查看全文查看/发表评论下载PDF阅读器

关闭