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| 术后重度疼痛患者使用镇痛药物的经济学评价 |
| Pharmacoeconomic Analysis of Analgesics in Patients with Severe Pain After Operation |
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| DOI： |
| 中文关键词: 镇痛药物 重度疼痛 胸外科手术 药物经济学 静脉自控镇痛泵 合理用药 |
| 英文关键词:Analgesics Severe pain Thoracic surgery Pharmacoeconomic Patient controlled intravenous analgesia Rational drug use |
| 基金项目:2017年浙江省药学会临床科研基金项目(编号：2017ZYC-A129) |
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| 中文摘要: |
| 摘 要 目的：对两种术后镇痛方案进行药物经济学评价，为临床合理用药提供指导。 方法：回顾性分析胸外科开胸术后重度疼痛患者使用静脉自控镇痛泵（patient controlled intravenous analgesia，PCIA）治疗的情况，87例病例根据镇痛药物分为A组（地佐辛+右美托咪定+托烷司琼）和B组（地佐辛+布托啡诺+托烷司琼），用药48 h后观察镇痛疗效和药品不良反应，并采用成本 效果分析方法对两组治疗方案进行药物经济学评价。结果：A、B两组疼痛缓解率分别为97.78%，97.62%，差异无统计学意义（P>0.05）。各组均无严重药品不良反应出现，药品不良反应发生率分别为13.33%，4.76%，差异无统计学意义（P>0.05）。A、B组人均成本分别为1 092.14，729.91元，成本 效果比分别为11.17，7.48。 结论：手术48 h后，两组方案疼痛缓解率相当，B组花费较低，且药品不良反应发生率也较低。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the cost effectiveness of two analgesic regimens for analgesia after thoracic surgery, and then to provide guidance for rational drug use in clinical practice. Methods:87 patients were treated with patient controlled intravenous analgesia (PCIA) and divided into Group A (desozin + dexmedetomidine + tropisetron) and Group B (desozin + butorphanol + tropisetron ) in light of the medication in the analgesic pump to find out their reactions after taking 48 hours analgesic treatment and to conduct a pharmacoeconomic analysis of the cost effectiveness of the two treatment options. Results:The pain relief rates of Group A and Group B were 97.78% and 97.62% respectively, and there was no significant difference between the two groups (P>0.05). The rates of adverse reactions in Group A and Group B were 13.33% and 4.76% respectively (P>0.05), mainly represented by hypotension, nausea and vomiting. The costs per capita in Group A and Group B were 1 092.14 and 729.91 respectively, and the cost effectiveness ratios were 11.17 and 7.48 respectively. Conclusion:Based on these findings, there was no significant difference in pain relief rate between the two groups within 48 hours after surgery and Group B cost less money and witnessed fewer adverse reactions. |
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