| ABSTRACT Objective: To investigate the safety and the optimal dose of nalbuphine combined with propofol in painless artificial abortion. Methods:300 cases of patients undergoing painless abortion were randomly divided into three groups, group N1 (nalbuphine 0.10 mg·kg-1); group N2 (nalbuphine 0.15 mg·kg-1); group N3 (nalbuphine 0.20 mg·kg-1). Each group were given the corresponding dose nalbuphine, after 5 min, the propofol was injected slowly. Then abortion was performed. The systolic pressure (SBP), heart rate (HR), pulse oxygen saturation (SpO2) were recorded at different time points, and other data were recorded including the propofol dosage, operation time, recovery time, time of departure from the hospital, assisted respiration, nausea and vomiting, dizziness, the 5 minute VAS score after wake and anesthesia effect etc. Results:The SBP compared with pre anesthesia in each group decreased significantly after anesthesia induction (P<0.05), but the SBP returned to normal when the patient awaked. There had no significant differences between the 3 groups about the SBP, HR and SpO2 at each time point（P>0.05）. The rates of patients with moderate and severe abdominal pain in group N2 and group N3 were significantly lower than those in group N1（P<0.05）, and the excellent anesthetic effect rate was also significantly superior to group N1 (P<0.05). The propofol dosage and the recovery time of group N1 was superior to group N2 and group N3 (P<0.05). The time of departure from the hospital and dizziness in group N1 and group N2 were significantly shorter or less than that in group N3 (P<0.05). Conclusion: This study suggested that 0.15 mg·kg-1 nalbuphine combined with appropriate propofol was effective and safe for painless abortion. |
