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| 术前应用聚维酮碘预防白内障人工晶体植入术后眼内炎疗效观察 |
| Clinical Efficacy of Preoperative Application of Povidone Iodine on Prevention of Postoperative Endophthalmitis in Patients Underwent Cataract Extraction and Intraocular Lens Implantation |
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| DOI： |
| 中文关键词: 眼内炎 白内障人工晶体植入术 聚维酮碘 临床疗效 |
| 英文关键词:Endophthalmitis Intraocular lens implantation Povidone iodine Clinical efficacy |
| 基金项目:浙江省科学技术项目（编号：2016C37142） |
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| 中文摘要: |
| 摘 要 目的：探讨术前应用聚维酮碘预防白内障人工晶体植入术后眼内炎的临床疗效及安全性。方法：202例行人工晶体植入术的年龄相关性白内障患者随机分为研究组和对照组（每组101例，患眼101只）。研究组术前结膜囊使用2.5%聚维酮碘，对照组术前结膜囊使用庆大霉素。比较两组患者眼内炎的发病率、自觉症状，分别于术前和术后1周、1个月、3个月后对其进行泪膜破裂时间检查(BUT)、角膜荧光染色检查(FL)、视力检查。结果：研究组术后无患者发生眼内炎，对照组术后6例（5.94%）患者发生眼内炎，研究组眼内炎发生率明显低于对照组（P<0.001）。术后两组患者异物感、结膜充血、角膜上皮水肿发生率比较差异无统计学意义（P<0.05）。术后1周两组患者FL评分均较术前明显升高（P<0.05），但两组间比较差异无统计学意义（P>0.05）；对照组术后1个月FL评分较术前升高（P<0.05），术后3个月恢复术前水平（P>0.05）；研究组术后3个月FL评分明显低于术前（P<0.05）；术后1个月、3个月研究组FL评分均明显低于对照组（P<0.05）。术后3个月，两组患者视力均较术前均明显改善（P<0.05），但两组间比较差异无统计学意义（P>0.05）。结论：白内障人工晶体植入术前应用聚维酮碘，术后眼内炎发生率明显降低，且不会影响视力的恢复，在临床上有推广使用价值。 |
| 英文摘要: |
| ABSTRACT Objective:To investigate clinical efficacy and safety of preoperative application of povidone iodine on prevention of postoperative endophthalmitis in patients underwent cataract extraction and intraocular lens implantation. Methods:202 age related cataract patients undergoing intraocular lens implantation were randomly divided into study group and control group (101 cases and 101 eyes in each group). In the study group, 2.5% povidone iodine was used in conjunctival sac before operation, while in the control group, gentamicin was used in conjunctival sac before operation. The incidence of endophthalmitis and symptoms were compared between the two groups. The break up time (BUT), corneal fluorescence staining (FL) and visual acuity were examined before and 1 week, 1 month and 3 months after operation. Results:No endophthalmitis occurred in the study group and 6 cases (5.94%) in the control group. The incidence of endophthalmitis in the study group was significantly lower than that in the control group (P<0.001). There was no significant difference in the incidence of foreign body sensation, conjunctival congestion and corneal epithelial edema between the two groups (P<0.05). One week after operation, FL scores of both groups were significantly higher than those before operation (P<0.05), but there was no significant difference between the two groups (P>0.05). FL scores in the control group at the first month after operation increased compared with that before operation (P<0.05), and the ccores returned to the preoperative level at the third months after operation (P>0.05). FL scores in the study group at the third months after operation were significantly lower than those before operation (P<0.05). , FL scores in the study group at the first month and third months after operation were significantly lower than those in the control group(P<0.05). Three months after operation, the visual acuity of the two groups was significantly improved compared with that before operation (P<0.05), but there was no significant difference between the two groups (P>0.05). Conclusion:The application of povidone iodine before cataract intraocular lens implantation can significantly reduce the incidence of endophthalmitis after cataract implantation without affecting the recovery of visual acuity. It has the value of popularization and application in clinic. |
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