| ABSTRACT Objective: To observe the mechanism of Sofren injection in the treatment of elderly patients with unstable angina pectoris (UAP) and provide theoretical basis for clinical application. Methods:74 UAP patients who met the inclusion criteria were randomly divided into control group (35 cases) and rhodiola group (39 cases). Both groups were treated with routine treatment. The rhodiola group was treated with intravenous drip of Sofren injection. Both groups were treated for 14 days. The related scores of angina pectoris and changes of electrocardiogram were observed before and after treatment. The levels of SAA, IL 6, TNF α, Ps, sICAM 1 and vWF in serum were detected by ELISA. Real time Quantitative Fluorescent PCR was used to detect LncRNA TUG1 and LncRNA MIAT in peripheral blood.Results:Compared with treatment before, the symptom scores of angina were significantly decreased in both groups (P<0.05), and the levels of SAA, IL 6, TNF α, Ps, sICAM 1, and vWF were all decreased. The expression of LncRNA TUG1 in serum was increased, and the expression of LncRNA MIAT was decreased (P<0.05). Compared with the control group, the scores of angina pectoris, serum SSA, IL 6, TNF α, Ps, sICAM 1 and vWF levels, and the expression of LncRNA MIAT were decreased in the rhodiola group, and the expression of LncRNA TUG1 in the serum was increased. The effect was more significant (P<0.05). Conclusion:Sofren injection has a good effect in the treatment of elderly patients with UAP. Its mechanism may be related to the regulation of LncRNA TUG1, LncRNA MIAT expression, and thus reduced the expression of inflammation related factors and vascular endothelial damage related factors. |
