| ABSTRACT Objective: To explore the clinical efficacy of Guchang capsule combined with Bifidobacterium tetrabacterial tablets in the treatment of diarrhea predominant irritable bowel syndrome (IBS D) and its effect on intestinal flora and intestinal mucosal barrier function. Methods: 86 patients with IBS-D diagnosed in our hospital were randomly divided into control group (n=39) and observation group (n=47). The control group was treated by oral administration of Bifidobacterium tetrabacterial tablets, while the observation group was treated with Guchang capsule on the basis of the treatment of the control group. The course of treatment was one month. The symptoms and clinical efficacy of the two groups were evaluated, and the improvement efficiency of defecation symptoms and the nature of stool was evaluated. The colony numbers of enterobacter, enterococcus, bifidobacterium, Lactobacillus and yeast like fungi in the intestinal tract and the levels of D-lactic acid (D-LA), tumor necrosis factor-α (TNF-α) and milk fat globule epidermal growth factor 8 (MFG-E8) in serum were measured before and after treatment in the two groups. Results:The clinical effective rate and the improvement of stool quality in the observation group were significantly higher than those of the control group (P<0.05). After treatment, the degree of abdominal pain, days of abdominal pain, degree of abdominal distension, defecation satisfaction, life disturbance, IBS-BSS, daily defecation times and urgent defecation days in 10 days in the observation group were all lower than those before treatment (P<0.05), which were better than those in the control group (P<0.05). Compared with before treatment, the number of enterobacteria and yeast like fungi colonies were decreased, the number of enterococcus, Bifidobacterium and Lactobacillus colonies were increased, the serum D-LA, TNF-α was decreased, and MFG E8 was increased in the observation group (P<0.05), and the above indexes were better than those in the control group after treatment, which were also superior to the control group (P<0.05). Conclusion:Guchang capsule combined with Bifidobacterium tetrabacterial tablets has good clinical efficacy in the treatment of diarrhea predominant irritable bowel syndrome. Its mechanism is related to improving intestinal flora and enhancing intestinal mucosal barrier function. |
