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| 替加环素治疗耐碳青霉烯类鲍曼不动杆菌肺炎疗效的回顾性研究 |
| Restropective Study of Efficacy of Tigecycline in Pneumonia Caused by Carbapenem resistant Acinetobacter baumannii |
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| DOI： |
| 中文关键词: 替加环素 医院获得性肺炎 鲍曼不动杆菌 疗效 |
| 英文关键词:Tegicycline Hospital acquired pneumonia Acinetobacter baumannii Efficacy |
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| 中文摘要: |
| 摘 要 目的：分析替加环素治疗耐碳青霉烯类鲍曼不动杆菌（CRAB）所致医院获得性肺炎（HAP）的疗效及影响因素。方法：采用回顾性研究方法，收集2015年1月～2017年6月在解放军第458医院接受过替加环素治疗的CRAB所致HAP患者资料，评定其临床疗效和微生物学疗效，对临床治愈和无效患者的基线资料和疗效指标进行比较分析，以Logistic回归分析统计替加环素疗效的独立影响因素。结果：共纳入128例患者，其中临床治愈80例，无效48例，治愈率62.5%。95.0%的治愈患者为联合治疗。无效组患者的治疗前WBC计数明显高于治愈组（P＜0.05）；接受替加环素治疗前抗菌药使用时间无效组明显长于治愈组（P＜0.05）。Logistic回归分析显示，APACHE Ⅱ评分高的患者治愈的概率是评分低患者的0.699倍（P＜0.05）。结论：替加环素治疗耐碳青霉烯类鲍曼不动杆菌所致医院获得性肺炎具有较好疗效，患者APACHE Ⅱ评分可能是替加环素疗效的独立影响因素。 |
| 英文摘要: |
| ABSTRACT Objective:To analyze the efficacy and influencing factors of tigecycline in the treatment of hospital acquired pneumonia caused by carbapenem resistant Acinetobacter baumannii. Methods: A retrospective study was carried out in the 458th Hospital of PLA. Data from patients with hospital acquired pneumonia being caused by carbapenem resistant Acinetobacter baumannii and being treated with tigecycline were collected from January 2015 to June 2017. The clinical curative effect and microbiological effect were evaluated. The baseline data and curative index between clinically cured and ineffective patients were compared. The independent influencing factor of tigecycline was analyzed using Logistic regression analysis. Results: A total of 128 patients were included, of which 80 patients were clinically cured and 48 patients were ineffective. The cure rate was 62.5%, and 95.0% of the cured patients were treated with combination therapy. WBC count was significantly higher in the invalid group than that in the cure group (P＜0.05). The time of using antibacterial drug before treatment with tigecycline was significantly longer in the invalid group than that in the cure group (P＜0.05). Logistic regression analysis showed that patients with high APACHE Ⅱ scores were 0.699 times more likely to be cured than those with lower scores (P＜0.05). 〖WTHZ〗Conclusion:〖WTBZ〗Tigecycline had better curative effect on hospital acquired pneumonia caused by carbapenem resistant Acinetobacter baumannii. The APACHE Ⅱ score of patients might be an independent factor influencing the efficacy of tegicycline. |
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