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| 不同种类糖皮质激素治疗儿童原发性肾病综合征的回顾性研究 |
| A Retrospective Study of the Glucocorticoids in the Treatment of Primary Nephrotic Syndrome in Children |
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| DOI： |
| 中文关键词: 肾病综合征 甲泼尼龙 泼尼松 儿童 |
| 英文关键词:Nephritic syndrome Methylprednisone Prednisone Child |
| 基金项目: |
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| 摘要点击次数: 924 |
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| 中文摘要: |
| 摘 要 目的：了解两种糖皮质激素治疗儿童原发性肾病综合征的疗效及不良反应。方法：采用回顾性分析方法，收集吉林大学第一医院2017年1月～2018年1月收治的原发性肾病综合征患儿病例资料，依据临床治疗方案不同分为泼尼松治疗组（35例）和甲泼尼龙治疗组（30例）。比较两组患儿的临床症状、治疗效应及不良反应。 结果：两组患儿激素反应（敏感、耐药、依赖）差异无统计学意义（P＞0.05）。对于激素敏感和依赖的患儿，甲泼尼龙组尿蛋白转阴时间短于泼尼松组（P＜0.05）。两组患儿的感染症状不良反应差异有统计学意义（P＜0.05）。结论：甲泼尼龙对于原发性儿童肾病综合征的诱导缓解优于泼尼松，但在不良反应方面尚需进一步研究。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the efficacy and adverse reaction of two kinds of glucocorticoids in the therapy of the primary nephritic syndrome in children. Methods:Clinical data of children with primary nephritic syndrome who had received treatment in the First Hospital of Jilin University from January 2017 to January 2018 were analyzed retrospectively. They were divided into two groups according to the different clinical treatments, 35 children given the treatment of prednisone were set as the first group, while 30 children with the treatment of methylprednisone were set as the second, group. The clinical improvement of symptoms, effective adverse reaction were compared. Results:No statistical significances were found between two groups in response to glucocorticoids, including sensitivity, steroid dependence and steroid resistance (P>0.05). For sensitive and dependent children, time for urinary protein negative conversion was shorter in methylprednisone group than that in the prednisone group with statistical significance (P<0.05). There were significant differences in adverse reactions to infection symptoms between the two groups (P<0.05). Conclusion:Methylprednisone superior to prednisone in inducing remission in nephritic syndrome. But there is no certain definition when it comes to the adverse reaction. |
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