| ABSTRACT Objective:To investigate the influence factors and rational treatment of allergic shock caused by Ampicillin Sodium for injection, so as to provide a reference for clinical treatment. Methods: 71 allergic shock cases (including 5 death) caused by Ampicillin Sodium for injection in Hebei ADR monitoring system between 2015 January and 2017 June were analyzed, according to sex, age, indication, menstruum, single dose, frequency, route of medication, hierarchy of medical institutions and prognosis. Results: Allergic shock caused by Ampicillin Sodium for injection was related to the off label use of drug, the main reason was the use of over single dose and over dose frequency, the use of unsuitable solvents, and no skin test before use. The prognosis had tight relationship with timely diagnosis and rational treatment. Conclusion:Allergic shock cases caused by ampicillin sodium for injection had a relatively high frequency in actual use. Safety monitoring and timely treatment was the effective way to decrease risk of allergic shock of Ampicillin Sodium for injection. |
