| ABSTRACT Objective: To explore the characteristics of adverse drug reactions/events induced by GLP 1 agonist preparation. Methods:Using computer retrieval the database such as CNKI, Wanfang, PubMed, etc, the adverse reactions/events of GLP 1 agonist preparation were collected and analyzed, including exenatide,liraglutide, albiglutide, dulaglutide, benalutide, semaglutide. The patient factors, medicine factors and ADR/ADE relevant characteristics were examined respectively. Results: 31 articles and 32 cases were collected. 3 medication error events were removed and 1 case report was negative, 28 cases were included in the review analysis. It showed that the ADR/ADE of GLP 1 agonist preparation in women more than men, the majority adverse reactions occurred in the first two months after medication, ADR/ADE involving was major in digestive system，urogenital system and skin accessories. The most notable ADRs were pancreatitis and acute kidney injury. Renal insufficiency, or combined with ARBs±diuretics might be a risk factor for acute renal injury, possibly due to severe vomiting and dehydration leading to hypotension and insufficient renal blood flow. Conclusion:GLP 1 agonist preparation was safe, for those with high risk factors of pancreatitis and acute kidney injury, the pharmacist should strengthen the monitoring and follow up, and pay attention to the symptoms of abdominal pain, severe vomiting, dehydration and no urine, to avoid serious adverse events. |
