| ABSTRACT Objective:To understand the characteristics of children’s anti epileptic drug(AEDs) adverse reactions (ADR) in Baoshan City, Yunnan Province so as to provide reference for promoting the rational use of AEDs. Methods:From the National Adverse Drug Reaction Monitoring Network, 325 ADR reports of children with AEDs reported in the hospital from October 2008 to October 2018 in Baoshan City were collected. The basic conditions, AEDs classification, ADR involvement system and clinical manifestations, ADR grading and correlation evaluation results, case outcomes of children were statistically analyzed. Results: Among the 325 ADR reports of children with AEDs, the ratio of male to female was 1.1∶1.0 (169∶156); Under the age of 6 years old accounted for 58.5%. There were 242 cases (74.5%) of ADR caused by traditional AEDs, and 83 cases (25.5%) of ADR caused by new AEDs. The most common organs or systems involved in ADR were the skin and its attachments, followed by the digestive system and the nervous system. Of the 325 patients with ADR, 33 (9.50%) had severe ADR, 11 (3.38%) had new general ADR, and 1 (0.31%) had new severe ADR. Severe ADR caused by traditional AEDs mainly including skin damage caused by carbamazepine and liver function damage caused by VPA. The severe ADR caused by new AEDs was mainly skin damage and hyponatremia caused by oxcarbazepine and lamotrigine. 176 cases (54.15%) of ADR occurred within 24 hours after administration. 〖WTHZ〗Conclusion:〖WTBZ〗 Medical institutions should pay attention to ADR caused by AEDs and strengthen the clinical application of AEDs. |
