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| 比阿培南注射剂专项点评方法的构建及应用 |
| Construction and Application of Special Evaluation Method for Biapenem Injection |
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| DOI： |
| 中文关键词: 比阿培南 药物利用评价 加权逼近理想解排序法 |
| 英文关键词:Biapenem Drug utilization evaluation Weighted TOPSIS |
| 基金项目: |
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| 中文摘要: |
| 摘 要 目的：建立一种比阿培南的药物利用评价标准和评价方法，为其他抗菌药物的专项点评提供借鉴。方法：抽取某院2017年7月～2018年6月临床使用比阿培南的病历271份，采用基于限定日剂量（DDD）/限定日浓度（DDC）的药物利用评价方法和基于属性层次（AHM）的加权逼近理想解排序法（TOPSIS）分别评价比阿培南临床使用的合理性。结果：基于DDD/DDC的药物利用评价结果显示，比阿培南临床使用剂量基本合理，存在超浓度给药的现象。全年均值显示，平均用药频度（aDDDs/aDDCs）=0.673 0/2.692 2，药物利用指数（dDUI/cDUI）=0.840 2/3.361 0，采用DDC评价某药临床使用合理性比DDD更敏感。基于AHM的加权TOPSIS法研究结果显示，271份使用比阿培南的病历中，合理病历110份（40.59%），基本合理病历115份（42.43%），不合理病历46份（16.97%）。结论：建立的评价方法可有效评价比阿培南临床使用合理性，值得进一步研究和推广应用。 |
| 英文摘要: |
| ABSTRACT Objective:To establish a drug utilization evaluation standard and evaluation method for biapenem, and provide reference for the special evaluation of other antibiotics. Methods:271 electronic medical records of Biapenem in a hospital from July 2017 to June 2018 were collected. The rationality of Biapenem in clinical use was evaluated by defined daily dose（DDD）/defined daily concentration (DDC) and AHM based weighted TOPSIS. Results:Based on DDD/DDC drug utilization evaluation results, the clinical dose of biapenem was basically reasonable, and there was a phenomenon of over concentration administration (annual average showed aDDDs/aDDCs=0.673 0/2.692 2, dDUI/cDUI=0.840 2/3.361 0). The use of DDC to evaluate the rationality of a clinical use of a drug was more sensitive than a DDD. AHM based weighted TOPSIS study showed that 271 cases of biapenem had a reasonable medical record of 110 (40.59%), a basically reasonable medical record of 115 (42.43%), and an unreasonable medical record of 46 (16.97%). Conclusion:This evaluation method can effectively evaluate the rationality of clinical use of drugs, and it is worthy of further research and application. |
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