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基于关联规则的中药治疗血管性痴呆用药规律分析
Chinese Medicine Treatment of Vascular Dementia Based on Association Rules and Factor Analysis
  
DOI:
中文关键词:  血管性痴呆  中药  关联规则  因子分析
英文关键词:Vascular dementia  Traditional Chinese medicine  Association rules  Factor analysis
基金项目:国家国际合作基地项目(编号:2016 65),河南省产学研项目(编号:182107000029)
作者单位
周雨慧1.2 芦锰1.2 苗明三1 1.河南中医药大学研究生院 郑州450000 2.河北中医学院中西医结合学院内科教研室 
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中文摘要:
      摘 要 目的:探讨中医药治疗血管性痴呆的用药规律。 方法:以血管性痴呆为主题词,收集、整理CNKI数据库(2014年1月1日~2018年11月30日)中收载治疗血管性痴呆的中药方剂,建立血管性痴呆的中药方剂文献研究数据库,采用数据挖掘技术对其用药规律进行分析。 结果:纳入符合标准的72篇期刊文献中,共涉及74首中药方剂和142味中药,中药频数共计840次。其中使用频数≥5次的单味中药共有51种,累计出现680次,治疗血管性痴呆的核心药物有石菖蒲、黄芪、川芎、丹参等,中药功效以补虚药、活血化瘀药、开窍药、安神药、利水渗湿药、化痰止咳平喘药为主。药性以温性为主,药味甘、辛、苦最为常见,归经与五脏有关占总频次的80.75%。通过关联规则分析中发现关联强度最高的药对组合为11种,因子分析中提取5个公因子,系统聚类分析中归为4大类。 结论:治疗血管性痴呆的中药方剂中用药多以开窍、补虚、活血、祛痰为主。
英文摘要:
      ABSTRACT Objective:To explore the rule of traditional Chinese medicine for the treatment of vascular dementia. 〖WTHZ〗Methods:〖WTBZ〗Using vascular dementia as the key word, collect and organize the CNKI database (January 1, 2014 November 30, 2018) to collect the prescriptions for the treatment of vascular dementia, and establish a literature research database on vascular dementia prescriptions. Data mining technology analyzes the law of its medication. 〖WTHZ〗Results:〖WTBZ〗 A total of 72 prescriptions and 142 Chinese herbal medicines were included in the 72 journal articles that met the criteria. The frequency of traditional Chinese medicine was 840. Among them, there were 51 kinds of Chinese medicine frequency ≥5, and there were 680 occurrences in total. The core drugs for treating vascular dementia included Shichangpu, Astragalus, Chuanxiong and Salvia. The main efficacy category of traditional Chinese medicine were tonic, blood stasis, phlegm and tranquil medicine, Lishui osmotic drugs, Huayu Zhike antiasthmatic drugs. The medicinal properties were mainly temperate, and the medicinal tastes were sweet, spicy and bitter. The return to the five internal organs accounted for 80.75% of the total frequency. Through association rule analysis, the combination of the highest correlations was found to be 11 species, and the factor analysis extracted 5 common factors, which were classified into 4 categories in the system cluster analysis. 〖WTHZ〗Conclusion:〖WTBZ〗The treatment of vascular dementia prescriptions is mainly based on reclamation, tonic, blood circulation and phlegm.
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